Abstract
To investigate the effect of dopaminergic stimulation on gonadotrophin release, serum LH and FSH concentrations were measured during dopamine infusion (5 μ/kg/min for 120 min) in 8 healthy women in the early follicular phase, in 12 patients with hyperprolactinaemic amenorrhoea, in 5 subjects with premature ovarian failure and in 8 with polycystic ovarian disease and raised serum LH levels. Dopamine infusion produced a significant LH decrease compared with a control study using saline in all groups; there were no significant changes in FSH concentration. Between groups analysis showed a significantly greater LH fall in patients with polycystic ovarian disease than in the other groups. Dopamine inhibits LH release in healthy women and patients with anovulatory states of varying aetiology, and enhanced sensitivity to this inhibitory mechanism exists in polycystic ovarian disease. This finding suggests reduced dopamine activity at the median eminence level in this condition.
| Original language | English |
|---|---|
| Pages (from-to) | 436-440 |
| Number of pages | 5 |
| Journal | Acta Endocrinologica |
| Volume | 97 |
| Issue number | 4 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Inhibition of luteinizing hormone release by dopamine infusion in healthy women and in various pathophysiological conditions. / Ferrari, C.; Rampini, P.; Malinverni, A.; Scarduelli, C.; Benco, R.; Caldara, R.; Barbieri, C.; Testori, G.; Crosignani, P. G.
In: Acta Endocrinologica, Vol. 97, No. 4, 1981, p. 436-440.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of luteinizing hormone release by dopamine infusion in healthy women and in various pathophysiological conditions
AU - Ferrari, C.
AU - Rampini, P.
AU - Malinverni, A.
AU - Scarduelli, C.
AU - Benco, R.
AU - Caldara, R.
AU - Barbieri, C.
AU - Testori, G.
AU - Crosignani, P. G.
PY - 1981
Y1 - 1981
N2 - To investigate the effect of dopaminergic stimulation on gonadotrophin release, serum LH and FSH concentrations were measured during dopamine infusion (5 μ/kg/min for 120 min) in 8 healthy women in the early follicular phase, in 12 patients with hyperprolactinaemic amenorrhoea, in 5 subjects with premature ovarian failure and in 8 with polycystic ovarian disease and raised serum LH levels. Dopamine infusion produced a significant LH decrease compared with a control study using saline in all groups; there were no significant changes in FSH concentration. Between groups analysis showed a significantly greater LH fall in patients with polycystic ovarian disease than in the other groups. Dopamine inhibits LH release in healthy women and patients with anovulatory states of varying aetiology, and enhanced sensitivity to this inhibitory mechanism exists in polycystic ovarian disease. This finding suggests reduced dopamine activity at the median eminence level in this condition.
AB - To investigate the effect of dopaminergic stimulation on gonadotrophin release, serum LH and FSH concentrations were measured during dopamine infusion (5 μ/kg/min for 120 min) in 8 healthy women in the early follicular phase, in 12 patients with hyperprolactinaemic amenorrhoea, in 5 subjects with premature ovarian failure and in 8 with polycystic ovarian disease and raised serum LH levels. Dopamine infusion produced a significant LH decrease compared with a control study using saline in all groups; there were no significant changes in FSH concentration. Between groups analysis showed a significantly greater LH fall in patients with polycystic ovarian disease than in the other groups. Dopamine inhibits LH release in healthy women and patients with anovulatory states of varying aetiology, and enhanced sensitivity to this inhibitory mechanism exists in polycystic ovarian disease. This finding suggests reduced dopamine activity at the median eminence level in this condition.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019794333&partnerID=8YFLogxK
M3 - Article
C2 - 6791426
AN - SCOPUS:0019794333
VL - 97
SP - 436
EP - 440
JO - Acta Endocrinologica
JF - Acta Endocrinologica
SN - 0001-5598
IS - 4
ER -