Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection

Stefano Bellosta, Monica Gomaraschi, Monica Canavesi, Giuseppe Rossoni, Mara Monetti, Guido Franceschini, Laura Calabresi

Research output: Contribution to journalArticlepeer-review

Abstract

High density lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the reduction of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection.

Original languageEnglish
Pages (from-to)5974-5978
Number of pages5
JournalFEBS Letters
Volume580
Issue number25
DOIs
Publication statusPublished - Oct 30 2006

Keywords

  • Gelatinase A
  • High density lipoproteins
  • Ischemia/reperfusion injury
  • Matrix metalloproteinases
  • Myocardial ischemia

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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