Abstract
High density lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the reduction of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection.
Original language | English |
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Pages (from-to) | 5974-5978 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 580 |
Issue number | 25 |
DOIs | |
Publication status | Published - Oct 30 2006 |
Keywords
- Gelatinase A
- High density lipoproteins
- Ischemia/reperfusion injury
- Matrix metalloproteinases
- Myocardial ischemia
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology