Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection

Stefano Bellosta; Monica Gomaraschi; Monica Canavesi; Giuseppe Rossoni; Mara Monetti; Guido Franceschini; Laura Calabresi

doi:10.1016/j.febslet.2006.10.006

Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection

Stefano Bellosta, Monica Gomaraschi, Monica Canavesi, Giuseppe Rossoni, Mara Monetti, Guido Franceschini, Laura Calabresi

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

High density lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the reduction of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection.

Original language	English
Pages (from-to)	5974-5978
Number of pages	5
Journal	FEBS Letters
Volume	580
Issue number	25
DOIs	https://doi.org/10.1016/j.febslet.2006.10.006
Publication status	Published - Oct 30 2006

Keywords

Gelatinase A
High density lipoproteins
Ischemia/reperfusion injury
Matrix metalloproteinases
Myocardial ischemia

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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title = "Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection",

abstract = "High density lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the reduction of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection.",

keywords = "Gelatinase A, High density lipoproteins, Ischemia/reperfusion injury, Matrix metalloproteinases, Myocardial ischemia",

author = "Stefano Bellosta and Monica Gomaraschi and Monica Canavesi and Giuseppe Rossoni and Mara Monetti and Guido Franceschini and Laura Calabresi",

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AU - Bellosta, Stefano

AU - Gomaraschi, Monica

AU - Canavesi, Monica

AU - Rossoni, Giuseppe

AU - Monetti, Mara

AU - Franceschini, Guido

AU - Calabresi, Laura

PY - 2006/10/30

Y1 - 2006/10/30

N2 - High density lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the reduction of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection.

AB - High density lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the reduction of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection.

KW - Gelatinase A

KW - High density lipoproteins

KW - Ischemia/reperfusion injury

KW - Matrix metalloproteinases

KW - Myocardial ischemia

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Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection

Abstract

Keywords

ASJC Scopus subject areas

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