Inhibition of murine bone marrow colonies growth by adenosine containing nucleotides

G. L. Bianchi Scarra, R. Ghio, R. Ellero, F. Ajmar

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of various compounds: NAD+, NADP+, Adenosine Diphospho-Ribose, Nicotinamide, Ribose 5 Phosphate, Adenosine, cAMP, cGMP, on the growth of granulocytic and erythroid mouse bone marrow colonies (CFU(C) and CFU(E)) was evaluated. The substances were either added directly to the semi-solid culture system, to obtain a continuous exposure during colony growth, or preincubated for various times with bone marrow cells before plating. The results indicate an inhibitory effect on the number of both colonies of several adenosine containing compounds. The effect is concentration dependent and irreversible. CFU(E) and CFU(C) show different sensitivity to the inhibition.

Original languageEnglish
Pages (from-to)40-42
Number of pages3
JournalBiomedicine
Volume31
Issue number2
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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