Inhibition of murine bone marrow colonies growth by adenosine containing nucleotides

G. L. Bianchi Scarra; R. Ghio; R. Ellero; F. Ajmar

Inhibition of murine bone marrow colonies growth by adenosine containing nucleotides

G. L. Bianchi Scarra, R. Ghio, R. Ellero, F. Ajmar

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of various compounds: NAD⁺, NADP⁺, Adenosine Diphospho-Ribose, Nicotinamide, Ribose 5 Phosphate, Adenosine, cAMP, cGMP, on the growth of granulocytic and erythroid mouse bone marrow colonies (CFU(C) and CFU(E)) was evaluated. The substances were either added directly to the semi-solid culture system, to obtain a continuous exposure during colony growth, or preincubated for various times with bone marrow cells before plating. The results indicate an inhibitory effect on the number of both colonies of several adenosine containing compounds. The effect is concentration dependent and irreversible. CFU(E) and CFU(C) show different sensitivity to the inhibition.

Original language	English
Pages (from-to)	40-42
Number of pages	3
Journal	Biomedicine
Volume	31
Issue number	2
Publication status	Published - 1979

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Inhibition of murine bone marrow colonies growth by adenosine containing nucleotides",

abstract = "The effect of various compounds: NAD+, NADP+, Adenosine Diphospho-Ribose, Nicotinamide, Ribose 5 Phosphate, Adenosine, cAMP, cGMP, on the growth of granulocytic and erythroid mouse bone marrow colonies (CFU(C) and CFU(E)) was evaluated. The substances were either added directly to the semi-solid culture system, to obtain a continuous exposure during colony growth, or preincubated for various times with bone marrow cells before plating. The results indicate an inhibitory effect on the number of both colonies of several adenosine containing compounds. The effect is concentration dependent and irreversible. CFU(E) and CFU(C) show different sensitivity to the inhibition.",

author = "{Bianchi Scarra}, {G. L.} and R. Ghio and R. Ellero and F. Ajmar",

year = "1979",

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T1 - Inhibition of murine bone marrow colonies growth by adenosine containing nucleotides

AU - Bianchi Scarra, G. L.

AU - Ghio, R.

AU - Ellero, R.

AU - Ajmar, F.

PY - 1979

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N2 - The effect of various compounds: NAD+, NADP+, Adenosine Diphospho-Ribose, Nicotinamide, Ribose 5 Phosphate, Adenosine, cAMP, cGMP, on the growth of granulocytic and erythroid mouse bone marrow colonies (CFU(C) and CFU(E)) was evaluated. The substances were either added directly to the semi-solid culture system, to obtain a continuous exposure during colony growth, or preincubated for various times with bone marrow cells before plating. The results indicate an inhibitory effect on the number of both colonies of several adenosine containing compounds. The effect is concentration dependent and irreversible. CFU(E) and CFU(C) show different sensitivity to the inhibition.

AB - The effect of various compounds: NAD+, NADP+, Adenosine Diphospho-Ribose, Nicotinamide, Ribose 5 Phosphate, Adenosine, cAMP, cGMP, on the growth of granulocytic and erythroid mouse bone marrow colonies (CFU(C) and CFU(E)) was evaluated. The substances were either added directly to the semi-solid culture system, to obtain a continuous exposure during colony growth, or preincubated for various times with bone marrow cells before plating. The results indicate an inhibitory effect on the number of both colonies of several adenosine containing compounds. The effect is concentration dependent and irreversible. CFU(E) and CFU(C) show different sensitivity to the inhibition.

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