TY - JOUR
T1 - Inhibition of murine bone marrow colonies growth by adenosine containing nucleotides
AU - Bianchi Scarra, G. L.
AU - Ghio, R.
AU - Ellero, R.
AU - Ajmar, F.
PY - 1979
Y1 - 1979
N2 - The effect of various compounds: NAD+, NADP+, Adenosine Diphospho-Ribose, Nicotinamide, Ribose 5 Phosphate, Adenosine, cAMP, cGMP, on the growth of granulocytic and erythroid mouse bone marrow colonies (CFU(C) and CFU(E)) was evaluated. The substances were either added directly to the semi-solid culture system, to obtain a continuous exposure during colony growth, or preincubated for various times with bone marrow cells before plating. The results indicate an inhibitory effect on the number of both colonies of several adenosine containing compounds. The effect is concentration dependent and irreversible. CFU(E) and CFU(C) show different sensitivity to the inhibition.
AB - The effect of various compounds: NAD+, NADP+, Adenosine Diphospho-Ribose, Nicotinamide, Ribose 5 Phosphate, Adenosine, cAMP, cGMP, on the growth of granulocytic and erythroid mouse bone marrow colonies (CFU(C) and CFU(E)) was evaluated. The substances were either added directly to the semi-solid culture system, to obtain a continuous exposure during colony growth, or preincubated for various times with bone marrow cells before plating. The results indicate an inhibitory effect on the number of both colonies of several adenosine containing compounds. The effect is concentration dependent and irreversible. CFU(E) and CFU(C) show different sensitivity to the inhibition.
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M3 - Article
C2 - 476278
AN - SCOPUS:0018763092
VL - 31
SP - 40
EP - 42
JO - Biomedicine (India)
JF - Biomedicine (India)
SN - 0970-2067
IS - 2
ER -