Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat

Luigi Pulvirenti; Claudia Balducci; George F. Koob

doi:10.1016/S0028-3908(96)00152-9

Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat

Luigi Pulvirenti, Claudia Balducci, George F. Koob

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of a blockade of nitric oxide synthesis were studied in rats trained to self-administer cocaine intravenously. Pretreatment with Ng-nitro-1-arginine methyl ester (l-NAME; 10-50 mg/kg, intraperitoneally, twice daily for 4 days), significantly and dose-dependently suppressed the maintenance of intravenous cocaine self-administration and the absolute reward magnitude of cocaine. These results suggest that nitric oxide may play a role in cocaine abuse and dependence.

Original language	English
Pages (from-to)	1811-1814
Number of pages	4
Journal	Neuropharmacology
Volume	35
Issue number	12
DOIs	https://doi.org/10.1016/S0028-3908(96)00152-9
Publication status	Published - Dec 1996

Keywords

cocaine
drug dependence
l-NAME
nitric oxide

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Drug Discovery
Pharmacology

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