Abstract
The effects of a blockade of nitric oxide synthesis were studied in rats trained to self-administer cocaine intravenously. Pretreatment with Ng-nitro-1-arginine methyl ester (l-NAME; 10-50 mg/kg, intraperitoneally, twice daily for 4 days), significantly and dose-dependently suppressed the maintenance of intravenous cocaine self-administration and the absolute reward magnitude of cocaine. These results suggest that nitric oxide may play a role in cocaine abuse and dependence.
Original language | English |
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Pages (from-to) | 1811-1814 |
Number of pages | 4 |
Journal | Neuropharmacology |
Volume | 35 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 1996 |
Keywords
- cocaine
- drug dependence
- l-NAME
- nitric oxide
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery
- Pharmacology