Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat

Luigi Pulvirenti, Claudia Balducci, George F. Koob

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of a blockade of nitric oxide synthesis were studied in rats trained to self-administer cocaine intravenously. Pretreatment with Ng-nitro-1-arginine methyl ester (l-NAME; 10-50 mg/kg, intraperitoneally, twice daily for 4 days), significantly and dose-dependently suppressed the maintenance of intravenous cocaine self-administration and the absolute reward magnitude of cocaine. These results suggest that nitric oxide may play a role in cocaine abuse and dependence.

Original languageEnglish
Pages (from-to)1811-1814
Number of pages4
JournalNeuropharmacology
Volume35
Issue number12
DOIs
Publication statusPublished - Dec 1996

Keywords

  • cocaine
  • drug dependence
  • l-NAME
  • nitric oxide

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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