Inhibition of NK cell generation by corynebacterium parvum

Mario Piccoli, Giorgio Santoni, Angela Santoni, Luigi Frati, Ronald B. Herberman, Michael A. Chirigos

Research output: Contribution to journalArticlepeer-review


Treatment of mice with Corynebacterium parvum (Cp) resulted in a substantial decrease of splenic NK activity associated with a reduced number of LGL. Cp also inhibited in vitro augmentation of NK cytotoxicity by IFN or IL-2 as well as generation of LAK activity. Localization experiments by using radiolabelled LGL indicated that the lower number of LGL in the spleen was not attributable to a Cp-induced alteration of LGL homing. Finally Cp was found to affect the ability of bone marrow cells to reconstitute NK activity in lethally irradiated mice, indicating that it can interfere with development of NK cells from bone marrow progenitors.

Original languageEnglish
Pages (from-to)513-529
Number of pages17
JournalImmunopharmacology and Immunotoxicology
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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