Inhibition of phytohemagglutinin (PHA) induced human T-cell colonies by methylprednisolone

R. Ghio, V. Pistoia, M. Romagnoli, P. D'Elia, G. P. Boccaccio

Research output: Contribution to journalArticle

Abstract

The mechanisms underlying the inhibition of T-cell proliferation by methylprednisolone (MPS) have been investigated using a T-cell colony assay. Cell fractionation experiments have demonstrated that MPS exerted its effects at the level of both T-cells and monocytes. Thus, monocytes treated with MPS released a soluble factor that had suppressor activity on T-cell proliferation. Moreover, MPS directly blocked the proliferative capacity of T-cells, as demonstrated by the finding that MPS-treated T-cells formed reduced numbers of colonies even under optimal culture conditions and in the presence of exogenous IL-2.

Original languageEnglish
Pages (from-to)237-245
Number of pages9
JournalInternational Journal of Immunopharmacology
Volume10
Issue number3
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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