Inhibition of restenosis with β-emitting radiotherapy: Report of the proliferation reduction with vascular energy trial (PREVENT)

Albert E. Raizner, Stephen N. Oesterle, Ron Waksman, Patrick W. Serruys, Antonio Colombo, Yean Leng Lim, Alan C. Yeung, Wim J. Van Der Giessen, Lynn Vandertie, Joseph K. Chiu, Larry R. White, Peter J. Fitzgerald, Grzegorz L. Kauza, Nadir M. Ali

Research output: Contribution to journalArticle

Abstract

Background - Intracoronary γ- and β-radiation have reduced restenosis in animal models. In the clinical setting, the effectiveness of β-emitters has not been studied in a broad spectrum of patients, particularly those receiving stents. Methods and Results - A prospective, randomized, sham-controlled study of intracoronary radiotherapy with the β-emitting 32P source wire, using a centering catheter and automated source delivery unit, was conducted. A total of 105 patients with de novo (70%) or restenotic (30%) lesions who were treated by stenting (61%) or balloon angioplasty (39%) received 0 (control), 16, 20, or 24 Gy to a depth of 1 mm in the artery wall. Angiography at 6 months showed a target site late loss index of 11 ± 36% in radiotherapy patients versus 55 ± 30% in controls (P32P source is safe and highly effective in inhibiting restenosis at the target site after stent or balloon angioplasty. However, minimizing edge narrowing and late thrombotic events must be accomplished to maximize the clinical benefit of this modality.

Original languageEnglish
Pages (from-to)951-958
Number of pages8
JournalCirculation
Volume102
Issue number9
Publication statusPublished - Aug 29 2000

Keywords

  • Coronary disease
  • Radiation
  • Radioisotopes
  • Radiotherapy
  • Restenosis
  • Stents

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Raizner, A. E., Oesterle, S. N., Waksman, R., Serruys, P. W., Colombo, A., Lim, Y. L., Yeung, A. C., Van Der Giessen, W. J., Vandertie, L., Chiu, J. K., White, L. R., Fitzgerald, P. J., Kauza, G. L., & Ali, N. M. (2000). Inhibition of restenosis with β-emitting radiotherapy: Report of the proliferation reduction with vascular energy trial (PREVENT). Circulation, 102(9), 951-958.