Inhibition of Sendai virus replication by △12-prostaglandin J2: Induction of heat shock protein synthesis and alteration of protein glycosylation

C. Amici, A. T. Palamara, E. Garaci, M. G. Santoro

Research output: Contribution to journalArticle

Abstract

12-Prostaglandin J2 (△12-PGJ2), a natural dehydration product of prostaglandin D2 present in human body fluids, was shown to suppress Sendai virus replication in monkey kidney cells, at doses non-toxic to uninfected cells. Dramatic inhibition of virus production could be obtained at doses of △12-PGJ2 which did not inhibit cellular or viral protein synthesis, suggesting an effect on virus assembly and/or maturation. At the active concentration, △12-PGJ2 caused a decrease in glucosamine incorporation into the virus glycoproteins HN and F, and in at least one host cell polypeptide, while it did not affect most cellular glycoproteins and it induced the glycosylation of a 47-kDa cellular polypeptide. These effects were accompanied by the induction of heat shock protein synthesis, which was found to differ in its specificity and kinetics from induction by prostaglandin A1.

Original languageEnglish
Pages (from-to)129-138
Number of pages10
JournalAntiviral Research
Volume19
Issue number2
DOIs
Publication statusPublished - 1992

    Fingerprint

Keywords

  • Cyclopentenone
  • Glycosylation
  • Heat shock protein
  • Prostaglandin
  • Sendai virus

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Cite this