Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the Eμ enhancer

Giovanna Cutrona, Elisabetta M. Carpaneto, Anna Ponzanelli, Massimo Ulivi, Enrico Millo, Sonia Scarfi, Silvio Roncella, Umberto Benatti, Lidia C. Boffa, Manlio Ferrarini

Research output: Contribution to journalArticle

Abstract

In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the Eμ enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a specific unique Eμ intronic sequence selectively blocked the expression of the c-myc oncogene under Eμ control but not of other c-myc alleles. This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications.

Original languageEnglish
Pages (from-to)6144-6148
Number of pages5
JournalCancer Research
Volume63
Issue number19
Publication statusPublished - Oct 1 2003

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Peptide Nucleic Acids
myc Genes
Burkitt Lymphoma
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 8
Immunoglobulin Heavy Chains
Tocopherols
Immunoglobulin E
Immunoglobulin M
B-Lymphocytes
Up-Regulation
Alleles
Gene Expression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cutrona, G., Carpaneto, E. M., Ponzanelli, A., Ulivi, M., Millo, E., Scarfi, S., ... Ferrarini, M. (2003). Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the Eμ enhancer. Cancer Research, 63(19), 6144-6148.

Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the Eμ enhancer. / Cutrona, Giovanna; Carpaneto, Elisabetta M.; Ponzanelli, Anna; Ulivi, Massimo; Millo, Enrico; Scarfi, Sonia; Roncella, Silvio; Benatti, Umberto; Boffa, Lidia C.; Ferrarini, Manlio.

In: Cancer Research, Vol. 63, No. 19, 01.10.2003, p. 6144-6148.

Research output: Contribution to journalArticle

Cutrona, G, Carpaneto, EM, Ponzanelli, A, Ulivi, M, Millo, E, Scarfi, S, Roncella, S, Benatti, U, Boffa, LC & Ferrarini, M 2003, 'Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the Eμ enhancer', Cancer Research, vol. 63, no. 19, pp. 6144-6148.
Cutrona G, Carpaneto EM, Ponzanelli A, Ulivi M, Millo E, Scarfi S et al. Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the Eμ enhancer. Cancer Research. 2003 Oct 1;63(19):6144-6148.
Cutrona, Giovanna ; Carpaneto, Elisabetta M. ; Ponzanelli, Anna ; Ulivi, Massimo ; Millo, Enrico ; Scarfi, Sonia ; Roncella, Silvio ; Benatti, Umberto ; Boffa, Lidia C. ; Ferrarini, Manlio. / Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the Eμ enhancer. In: Cancer Research. 2003 ; Vol. 63, No. 19. pp. 6144-6148.
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