In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the Eμ enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a specific unique Eμ intronic sequence selectively blocked the expression of the c-myc oncogene under Eμ control but not of other c-myc alleles. This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications.
|Number of pages||5|
|Publication status||Published - Oct 1 2003|
ASJC Scopus subject areas
- Cancer Research