Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the Eμ enhancer

Giovanna Cutrona, Elisabetta M. Carpaneto, Anna Ponzanelli, Massimo Ulivi, Enrico Millo, Sonia Scarfi, Silvio Roncella, Umberto Benatti, Lidia C. Boffa, Manlio Ferrarini

Research output: Contribution to journalArticlepeer-review

Abstract

In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the Eμ enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a specific unique Eμ intronic sequence selectively blocked the expression of the c-myc oncogene under Eμ control but not of other c-myc alleles. This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications.

Original languageEnglish
Pages (from-to)6144-6148
Number of pages5
JournalCancer Research
Volume63
Issue number19
Publication statusPublished - Oct 1 2003

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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