Abstract
It has been shown that murine tumors may express alien histocompatibility antigens encoded both by the MHC or by non-H-2 genes. In vivo immunization with allogeneic normal tissues was shown to protect syngeneic mice against neoplastic growth of sarcomas expressing the relevant antigen(s). With a similar approach, Zarling et al. could elicit a significant cell-mediated killing on autologous neoplastic targets by peripheral lymphocytes of certain patients sensitized in vitro to a pool of allogeneic normal cells. A comparable study was recently reported by the same group of workers in which solid murine tumors also appeared to be sensitive to the in vitro action of both T or non-T effectors generated by pool alloimmunization. In addition, Bortin et al. have described an in vivo system in which the development of AKR leukemias could be successfully prevented by grafting bone marrow of alloimmune H-2-compatible mice. We felt it important, therefore, to verify whether a similar antitumor activity directed to other types of lymphomas can be raised in vivo by alloimmunization with normal cells. We report here that alloimmunization with normal lymphoid cells of some strains dramatically increases the resistance of BALB/c mice to the growth of a syngeneic Moloney virus-induced lymphoma, YC8, previously shown to lack detectable amounts of alien H-2 antigens.
| Original language | English |
|---|---|
| Pages (from-to) | 1906-1909 |
| Number of pages | 4 |
| Journal | Transplantation Proceedings |
| Volume | 13 |
| Issue number | 4 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
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Inhibition of the YC8 lymphoma growth by alloimmunization with normal cells. / Parmiani, G.; Sensi, M. L.
In: Transplantation Proceedings, Vol. 13, No. 4, 1981, p. 1906-1909.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of the YC8 lymphoma growth by alloimmunization with normal cells
AU - Parmiani, G.
AU - Sensi, M. L.
PY - 1981
Y1 - 1981
N2 - It has been shown that murine tumors may express alien histocompatibility antigens encoded both by the MHC or by non-H-2 genes. In vivo immunization with allogeneic normal tissues was shown to protect syngeneic mice against neoplastic growth of sarcomas expressing the relevant antigen(s). With a similar approach, Zarling et al. could elicit a significant cell-mediated killing on autologous neoplastic targets by peripheral lymphocytes of certain patients sensitized in vitro to a pool of allogeneic normal cells. A comparable study was recently reported by the same group of workers in which solid murine tumors also appeared to be sensitive to the in vitro action of both T or non-T effectors generated by pool alloimmunization. In addition, Bortin et al. have described an in vivo system in which the development of AKR leukemias could be successfully prevented by grafting bone marrow of alloimmune H-2-compatible mice. We felt it important, therefore, to verify whether a similar antitumor activity directed to other types of lymphomas can be raised in vivo by alloimmunization with normal cells. We report here that alloimmunization with normal lymphoid cells of some strains dramatically increases the resistance of BALB/c mice to the growth of a syngeneic Moloney virus-induced lymphoma, YC8, previously shown to lack detectable amounts of alien H-2 antigens.
AB - It has been shown that murine tumors may express alien histocompatibility antigens encoded both by the MHC or by non-H-2 genes. In vivo immunization with allogeneic normal tissues was shown to protect syngeneic mice against neoplastic growth of sarcomas expressing the relevant antigen(s). With a similar approach, Zarling et al. could elicit a significant cell-mediated killing on autologous neoplastic targets by peripheral lymphocytes of certain patients sensitized in vitro to a pool of allogeneic normal cells. A comparable study was recently reported by the same group of workers in which solid murine tumors also appeared to be sensitive to the in vitro action of both T or non-T effectors generated by pool alloimmunization. In addition, Bortin et al. have described an in vivo system in which the development of AKR leukemias could be successfully prevented by grafting bone marrow of alloimmune H-2-compatible mice. We felt it important, therefore, to verify whether a similar antitumor activity directed to other types of lymphomas can be raised in vivo by alloimmunization with normal cells. We report here that alloimmunization with normal lymphoid cells of some strains dramatically increases the resistance of BALB/c mice to the growth of a syngeneic Moloney virus-induced lymphoma, YC8, previously shown to lack detectable amounts of alien H-2 antigens.
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M3 - Article
C2 - 7330975
AN - SCOPUS:0019833970
VL - 13
SP - 1906
EP - 1909
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 4
ER -