Inhibition of thromboxane biosynthesis by 3-pyridinol carboxypentyl ethers substituted with a hydroxylated octyl chain.

S. Conti, N. Desideri, S. Passaghe, M. N. Castagnoli, C. Cerletti, M. L. Stein

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Racemic 6-[4-(3'-hydroxy-1'-octenyl)-3-pyridyloxy]hexanoic and 6-[4-(3'-hydroxyoctyl)-3-pyridyloxy] exanoic acids have been synthesized and their activity as inhibitors of the biosynthesis of thromboxane A2 in human serum has been studied, in comparison with isomers having the eight-carbon chain in the 2 position. Very high, selective activity was found for the new 4-substituted 3-pyridinol ethers, whereas the 2-substituted compounds showed no action.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume40
Issue number2
Publication statusPublished - Feb 1988

Fingerprint

Thromboxane A2
Ethers
Thromboxanes
Carbon
Acids
Serum
3-hydroxypyridine

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Inhibition of thromboxane biosynthesis by 3-pyridinol carboxypentyl ethers substituted with a hydroxylated octyl chain. / Conti, S.; Desideri, N.; Passaghe, S.; Castagnoli, M. N.; Cerletti, C.; Stein, M. L.

In: Journal of Pharmacy and Pharmacology, Vol. 40, No. 2, 02.1988, p. 144-146.

Research output: Contribution to journalArticle

Conti, S. ; Desideri, N. ; Passaghe, S. ; Castagnoli, M. N. ; Cerletti, C. ; Stein, M. L. / Inhibition of thromboxane biosynthesis by 3-pyridinol carboxypentyl ethers substituted with a hydroxylated octyl chain. In: Journal of Pharmacy and Pharmacology. 1988 ; Vol. 40, No. 2. pp. 144-146.
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