Inhibition of thromboxane biosynthesis by 3-pyridinol carboxypentyl ethers substituted with a hydroxylated octyl chain.

S. Conti, N. Desideri, S. Passaghe, M. N. Castagnoli, C. Cerletti, M. L. Stein

Research output: Contribution to journalArticlepeer-review

Abstract

Racemic 6-[4-(3'-hydroxy-1'-octenyl)-3-pyridyloxy]hexanoic and 6-[4-(3'-hydroxyoctyl)-3-pyridyloxy] exanoic acids have been synthesized and their activity as inhibitors of the biosynthesis of thromboxane A2 in human serum has been studied, in comparison with isomers having the eight-carbon chain in the 2 position. Very high, selective activity was found for the new 4-substituted 3-pyridinol ethers, whereas the 2-substituted compounds showed no action.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume40
Issue number2
Publication statusPublished - Feb 1988

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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