TY - JOUR
T1 - Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors A and C isolation, physico-chemical characterization and biological properties
AU - Stefanelli, Stefania
AU - Sponga, Federica
AU - Ferrari, Pietro
AU - Sottani, Cristina
AU - Corti, Emiliana
AU - Brunati, Cristina
AU - Islam, Khalid
PY - 1996
Y1 - 1996
N2 - During the course of a screening program for inhibitors of myo-inositol monophosphatase we fermented the strain ATCC 20928, a known producer of L-671,776. We now show that this strain produces a complex of at least three sesquiterpenic compounds, L-671,776 (termed factor B) and two structurally related substances, termed factors A and C. Both factors A and C, like L-671,776, exhibited inhibitory activity against myo-inositol monophosphatase. Six other fungi producing the above mentioned compounds were also isolated and taxonomically characterized.
AB - During the course of a screening program for inhibitors of myo-inositol monophosphatase we fermented the strain ATCC 20928, a known producer of L-671,776. We now show that this strain produces a complex of at least three sesquiterpenic compounds, L-671,776 (termed factor B) and two structurally related substances, termed factors A and C. Both factors A and C, like L-671,776, exhibited inhibitory activity against myo-inositol monophosphatase. Six other fungi producing the above mentioned compounds were also isolated and taxonomically characterized.
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M3 - Article
C2 - 8784418
AN - SCOPUS:0029785254
VL - 49
SP - 611
EP - 616
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 7
ER -