Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors A and C isolation, physico-chemical characterization and biological properties

Stefania Stefanelli, Federica Sponga, Pietro Ferrari, Cristina Sottani, Emiliana Corti, Cristina Brunati, Khalid Islam

Research output: Contribution to journalArticlepeer-review

Abstract

During the course of a screening program for inhibitors of myo-inositol monophosphatase we fermented the strain ATCC 20928, a known producer of L-671,776. We now show that this strain produces a complex of at least three sesquiterpenic compounds, L-671,776 (termed factor B) and two structurally related substances, termed factors A and C. Both factors A and C, like L-671,776, exhibited inhibitory activity against myo-inositol monophosphatase. Six other fungi producing the above mentioned compounds were also isolated and taxonomically characterized.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalJournal of Antibiotics
Volume49
Issue number7
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

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