Inhibitory action of capsaicin on cholinergic responses induced by GABAA agonists in the guinea-pig ileum

Marcello Tonini, Luciano Onori, Carlo Alessandro Rizzi, Fabrizio De Ponti, Emilio Perucca, Piero Budassi, Antonio Crema

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Pretreatment of the guinea-pig ileum with capsaicin resulted consistently in depression of the neurogenic cholinergic contractions induced by the GABAA receptor agonists 3-aminopropane sulphonic acid (3-APS) and muscimol. Since capsaicin acts mainly by releasing and depleting substance P from its stores in intestinal nerves, it is likely that substance P plays a role in the response caused by GABAA-mimetic compounds. On the whole, our results suggest that excitatory responses to 3-APS and muscimol result from both direct and indirect activation of intrinsic intestinal cholinergic neurons innervating smooth muscle cells.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalEuropean Journal of Pharmacology
Volume128
Issue number3
DOIs
Publication statusPublished - Sep 9 1986

Fingerprint

GABA-A Receptor Agonists
Muscimol
Sulfonic Acids
Capsaicin
Substance P
Ileum
Cholinergic Agents
Guinea Pigs
Cholinergic Neurons
Smooth Muscle Myocytes

Keywords

  • (Guinea-pig)
  • 3-Aminopropane sul
  • Capsaicin
  • Cholinergic neurons
  • Ileum
  • Muscimol
  • phonic acid

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Inhibitory action of capsaicin on cholinergic responses induced by GABAA agonists in the guinea-pig ileum. / Tonini, Marcello; Onori, Luciano; Rizzi, Carlo Alessandro; De Ponti, Fabrizio; Perucca, Emilio; Budassi, Piero; Crema, Antonio.

In: European Journal of Pharmacology, Vol. 128, No. 3, 09.09.1986, p. 273-276.

Research output: Contribution to journalArticle

Tonini, Marcello ; Onori, Luciano ; Rizzi, Carlo Alessandro ; De Ponti, Fabrizio ; Perucca, Emilio ; Budassi, Piero ; Crema, Antonio. / Inhibitory action of capsaicin on cholinergic responses induced by GABAA agonists in the guinea-pig ileum. In: European Journal of Pharmacology. 1986 ; Vol. 128, No. 3. pp. 273-276.
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