Inhibitory activity of avibactam against selected β-lactamases expressed in an isogenic Escherichia coli strain

Tommaso Giani, Antonio Cannatelli, Vincenzo Di Pilato, Raymond Testa, Wright W. Nichols, Gian Maria Rossolini

Research output: Contribution to journalArticlepeer-review

Abstract

Avibactam restored the in-vitro antibacterial activity of ceftazidime, ceftaroline, and aztreonam against isogenic Escherichia coli expressing class A, class C, and class D β-lactamases. The enzymes included TEM and CTX-M extended spectrum β-lactamases, ACT, CMY and FOX AmpC-type enzymes, and carbapenemases including rarer KPC variants and OXA-139.

Original languageEnglish
Pages (from-to)83-85
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume86
Issue number1
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • AmpC-type β-lactamases
  • Avibactam β-lactam combinations
  • Carbapenemases
  • extended-spectrum β-lactamases
  • β-Lactamase inhibition

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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