TY - JOUR
T1 - Inhibitory and stimulatory effects of IL-10 on Human CD8+ T cells
AU - Groux, Hervé
AU - Bigler, Mike
AU - De Vries, Jan E.
AU - Roncarolo, Maria Grazia
PY - 1998/4/1
Y1 - 1998/4/1
N2 - IL-10 is a well-documented immunosuppressant that inhibits macrophage- dependent Ag presentation and CD4+ T cell proliferation in vitro. We report that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8+ T cells when added concomitantly with the Ag in the presence of APC. Moreover, the generation of allospecific cytotoxic activity is inhibited by IL-10. These effects are indirect and are mediated through inhibition of the costimulatory functions of APC. In contrast, IL-10 has no direct inhibitory effects on the proliferation of purified CD8+ T cells activated by anti-CD3 mAb and promotes the growth of activated CD8+ T cells in combination with low doses of IL-2. Taken together, these results indicate that IL-10 has differential effects on CD8+ T cells depending on their state of activation, which may explain both the enhancing and inhibitory effects observed after IL-10 treatment in different in vivo experimental models.
AB - IL-10 is a well-documented immunosuppressant that inhibits macrophage- dependent Ag presentation and CD4+ T cell proliferation in vitro. We report that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8+ T cells when added concomitantly with the Ag in the presence of APC. Moreover, the generation of allospecific cytotoxic activity is inhibited by IL-10. These effects are indirect and are mediated through inhibition of the costimulatory functions of APC. In contrast, IL-10 has no direct inhibitory effects on the proliferation of purified CD8+ T cells activated by anti-CD3 mAb and promotes the growth of activated CD8+ T cells in combination with low doses of IL-2. Taken together, these results indicate that IL-10 has differential effects on CD8+ T cells depending on their state of activation, which may explain both the enhancing and inhibitory effects observed after IL-10 treatment in different in vivo experimental models.
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M3 - Article
C2 - 9531274
AN - SCOPUS:0032055224
VL - 160
SP - 3188
EP - 3193
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 7
ER -