Inhibitory and stimulatory effects of IL-10 on Human CD8+ T cells

Hervé Groux, Mike Bigler, Jan E. De Vries, Maria Grazia Roncarolo

Research output: Contribution to journalArticlepeer-review

Abstract

IL-10 is a well-documented immunosuppressant that inhibits macrophage- dependent Ag presentation and CD4+ T cell proliferation in vitro. We report that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8+ T cells when added concomitantly with the Ag in the presence of APC. Moreover, the generation of allospecific cytotoxic activity is inhibited by IL-10. These effects are indirect and are mediated through inhibition of the costimulatory functions of APC. In contrast, IL-10 has no direct inhibitory effects on the proliferation of purified CD8+ T cells activated by anti-CD3 mAb and promotes the growth of activated CD8+ T cells in combination with low doses of IL-2. Taken together, these results indicate that IL-10 has differential effects on CD8+ T cells depending on their state of activation, which may explain both the enhancing and inhibitory effects observed after IL-10 treatment in different in vivo experimental models.

Original languageEnglish
Pages (from-to)3188-3193
Number of pages6
JournalJournal of Immunology
Volume160
Issue number7
Publication statusPublished - Apr 1 1998

ASJC Scopus subject areas

  • Immunology

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