Abstract
Administration of a small dose of prednisone markedly reduced (1) the PHA-induced expression of Ia antigens by T cells, (2) the stimulatory activity of Ia antigen-bearing T cells in autologous and allogeneic mixed lymphocyte reactions (MLRs), and (3) the proliferative response of T cells stimulated with autologous PHA-activated T cells or autologous or allogeneic non-T cells. The inhibitory effects of prednisone are reversible and are not detectable on T cells isolated from blood drawn 24 hr following prednisone administration. The kinetics of the prednisone-mediated inhibition of MLRs with autologous PHA-T cells is different from that of MLRs with autologous non-T cells. These data in conjunction with the information available in the literature suggest that the mechanisms underlying these two types of autologous MLRs are different.
| Original language | English |
|---|---|
| Pages (from-to) | 320-328 |
| Number of pages | 9 |
| Journal | Cellular Immunology |
| Volume | 80 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
Inhibitory effect of a low dose of prednisone on PHA-induced Ia antigen expression by human T cells and on proliferation of T cells stimulated with autologous PHA-T cells. / Indiveri, F.; Scudeletti, M.; Pende, D.; Barabino, A.; Russo, C.; Pellegrino, M. A.; Ferrone, S.
In: Cellular Immunology, Vol. 80, No. 2, 1983, p. 320-328.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Inhibitory effect of a low dose of prednisone on PHA-induced Ia antigen expression by human T cells and on proliferation of T cells stimulated with autologous PHA-T cells
AU - Indiveri, F.
AU - Scudeletti, M.
AU - Pende, D.
AU - Barabino, A.
AU - Russo, C.
AU - Pellegrino, M. A.
AU - Ferrone, S.
PY - 1983
Y1 - 1983
N2 - Administration of a small dose of prednisone markedly reduced (1) the PHA-induced expression of Ia antigens by T cells, (2) the stimulatory activity of Ia antigen-bearing T cells in autologous and allogeneic mixed lymphocyte reactions (MLRs), and (3) the proliferative response of T cells stimulated with autologous PHA-activated T cells or autologous or allogeneic non-T cells. The inhibitory effects of prednisone are reversible and are not detectable on T cells isolated from blood drawn 24 hr following prednisone administration. The kinetics of the prednisone-mediated inhibition of MLRs with autologous PHA-T cells is different from that of MLRs with autologous non-T cells. These data in conjunction with the information available in the literature suggest that the mechanisms underlying these two types of autologous MLRs are different.
AB - Administration of a small dose of prednisone markedly reduced (1) the PHA-induced expression of Ia antigens by T cells, (2) the stimulatory activity of Ia antigen-bearing T cells in autologous and allogeneic mixed lymphocyte reactions (MLRs), and (3) the proliferative response of T cells stimulated with autologous PHA-activated T cells or autologous or allogeneic non-T cells. The inhibitory effects of prednisone are reversible and are not detectable on T cells isolated from blood drawn 24 hr following prednisone administration. The kinetics of the prednisone-mediated inhibition of MLRs with autologous PHA-T cells is different from that of MLRs with autologous non-T cells. These data in conjunction with the information available in the literature suggest that the mechanisms underlying these two types of autologous MLRs are different.
UR - http://www.scopus.com/inward/record.url?scp=0020565574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020565574&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(83)90120-X
DO - 10.1016/0008-8749(83)90120-X
M3 - Article
C2 - 6411356
AN - SCOPUS:0020565574
VL - 80
SP - 320
EP - 328
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 2
ER -