Inhibitory effect of lithium on cAMP dependent phosphorylation system

Silvia Mori, Raffaella Zanardi, Maurizio Popoli, Enrico Smeraldi, Giorgio Racagni, Jorge Perez

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to assess the direct effect of lithium on cAMP dependent phosphorylation. The results show that lithium, but not rubidium, at therapeutic and high concentrations significantly decreases the cAMP stimulated MAP2 endogenous phosphorylation in microtubule fraction. An inhibitory effect of lithium has also been found using purified heat stable microtubule proteins phosphorylated by the catalytic subunit of PKA.These data suggest a direct effect of lithium on the cAMP dependent protein kinase.

Original languageEnglish
JournalLife Sciences
Volume59
Issue number9
Publication statusPublished - Jul 26 1996

Fingerprint

Phosphorylation
Lithium
Rubidium
Microtubule Proteins
Cyclic AMP-Dependent Protein Kinases
Microtubules
Catalytic Domain
Hot Temperature
Therapeutics

Keywords

  • cAMP-dependent protein kinase
  • lithium
  • MAPs
  • microtubules

ASJC Scopus subject areas

  • Pharmacology

Cite this

Mori, S., Zanardi, R., Popoli, M., Smeraldi, E., Racagni, G., & Perez, J. (1996). Inhibitory effect of lithium on cAMP dependent phosphorylation system. Life Sciences, 59(9).

Inhibitory effect of lithium on cAMP dependent phosphorylation system. / Mori, Silvia; Zanardi, Raffaella; Popoli, Maurizio; Smeraldi, Enrico; Racagni, Giorgio; Perez, Jorge.

In: Life Sciences, Vol. 59, No. 9, 26.07.1996.

Research output: Contribution to journalArticle

Mori, S, Zanardi, R, Popoli, M, Smeraldi, E, Racagni, G & Perez, J 1996, 'Inhibitory effect of lithium on cAMP dependent phosphorylation system', Life Sciences, vol. 59, no. 9.
Mori S, Zanardi R, Popoli M, Smeraldi E, Racagni G, Perez J. Inhibitory effect of lithium on cAMP dependent phosphorylation system. Life Sciences. 1996 Jul 26;59(9).
Mori, Silvia ; Zanardi, Raffaella ; Popoli, Maurizio ; Smeraldi, Enrico ; Racagni, Giorgio ; Perez, Jorge. / Inhibitory effect of lithium on cAMP dependent phosphorylation system. In: Life Sciences. 1996 ; Vol. 59, No. 9.
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