Inhibitory effect of prostacyclin (PGI2) on neutropenia induce by intravenous injection of platelet-activating-factor (PAF) in the rabbit

G. Camussi, C. Tetta, F. Bussolino

Research output: Contribution to journalArticlepeer-review

Abstract

Intravenous injection into rabbits of 1-O-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (synthetic Platelet-Activating Factor (PAF)) or PAF derived from rabbit basophils caused acute thrombocytopenia and neutropenia which was consequent to the formation of intravascular polymorphonuclear neutrophil (PMN) aggregates and to their sequestration in the microvasculature, primarily of the lung. Infusion of prostacyclin (PGI2; 10 ng/Kg/min to 50 ng/Kg/min) inhibited in a dose-dependent manner PAF-induced thrombocytopenia and neutropenia as well as the sequestration of PMN in the pulmonary capillary network.

Original languageEnglish
Pages (from-to)343-351
Number of pages9
JournalProstaglandins
Volume25
Issue number3
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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