Inhibitory effect of somatostatin on abnormal GH response to TRH in primary hypothyroidism

M. Baldini, A. Catania, A. Orsatti, M. G. Manfredi, P. Motta, L. Cantalamessa

Research output: Contribution to journalArticle

Abstract

Thyrotropin releasing hormone (TRH) does not promote GH secretion in normal subjects but it stimulates GH in a proportion of hypothyroid patients. In this study the response of GH to thyrotropin releasing hormone (TRH) was evaluated in 21 patients with primary hypothyroidism of different origin: 12 with autoimmune thyroiditis, 3 idiopathic, 3 congenital, 3 iatrogenic. 11 of these patients had never been treated, the others were tested after a drug-free period of at least two weeks. Basal plasma concentration of GH was normal in all patients; after TRH administration, a significant increase in plasma GH was observed in 4 patients. In these responsive patients, somatostatin infusion inhibited the abnormal GH response to TRH. It is suggested that the abnormal GH response to TRH in primary hypothyroidism might be caused by a relative deficiency of somatostatinergic control which is corrected by exogenous somatostatin administration.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalExperimental and Clinical Endocrinology
Volume99
Issue number2
Publication statusPublished - 1992

Keywords

  • GH
  • Primary hypothyroidism
  • Somatostatin
  • TRH

ASJC Scopus subject areas

  • Endocrinology

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    Baldini, M., Catania, A., Orsatti, A., Manfredi, M. G., Motta, P., & Cantalamessa, L. (1992). Inhibitory effect of somatostatin on abnormal GH response to TRH in primary hypothyroidism. Experimental and Clinical Endocrinology, 99(2), 80-83.