Inhibitory effects of centrally administered |ASU1–7| eel calcitonin on basal and stimulated prolactin release in rats

V. Sibilia, C. Netti, F. Guidobono, I. Villa, A. Pecile

Research output: Contribution to journalArticle

Abstract

We investigated the effects of /ASU1–7/eel calcitonin (ASU1–7 elCT) on basal and stimulated prolactin (PRL) release in male rats. /ASU1–7/eelCT was administered intracerebroventricularly (icv) into freely moving rats with indwelling catheters. The administration of /ASU1–7/eelCT (2.5 μ/rat, icv) significantly inhibited basal PRL secretion. When PRL secretion was stimulated by exposing rats to restraint stress, /ASU1–7/eelCT (250 ng; 800 ng; 2.5 μ/rat, icv) dose-relatedly inhibited the PRL surges at 10 min after stress. The same doses of icv /ASU1–7/eelCT were effective in inhibiting morphine (6 mg/kg, intracarotid, ia)-induced PRL release. No effect on stress-induced PRL secretion was observed when the peptide was administered intracarotid at the dose of 10 μ/rat. These results demonstrate that /ASU1–7/eelCT, as we previously observed with salmon calcitonin (sCT), has central inhibitory activity on PRL secretion, probably through enhancement of hypothalamic inhibitory pathways involved in the control of PRL.

Original languageEnglish
Pages (from-to)507-511
Number of pages5
JournalJournal of Endocrinological Investigation
Volume13
Issue number6
DOIs
Publication statusPublished - 1990

Keywords

  • morphine
  • PRL
  • stress
  • |ASU| eel calcitonin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Inhibitory effects of centrally administered |ASU<sup>1–7</sup>| eel calcitonin on basal and stimulated prolactin release in rats'. Together they form a unique fingerprint.

  • Cite this