Initial experience of three-minute freeze cycles using the second-generation cryoballoon ablation: Acute and short-term procedural outcomes

Gian Battista Chierchia, Giacomo Di Giovanni, Juan Sieira-Moret, Carlo De Asmundis, Giulio Conte, Moises Rodriguez-Manẽro, Ruben Casado-Arroyo, Giannis Baltogiannis, Gaetano Paparella, Giuseppe Ciconte, Andrea Sarkozy, Pedro Brugada

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The second-generation cryoballoon (CB-A) (Arctic Front Advance, Cryocath, Medtronic, MN, USA) might significantly improve procedural outcome with respect to the first-generation balloon. These technological improvements might also question the current recommendation of the need a 4-min freeze to achieve durable pulmonary vein isolation (PVI). Objective: The main aim of the study was to analyze the procedural efficacy of a 3-min freeze-thaw cycles with the CB-A balloon in the terms of rates of acute PVI and 6-month outcome. Methods: Patients having undergone CB-A for PAF or early persistent AF, with 3-min freeze-thaw cycles were consecutively included in our analysis. Acute procedural success was measured in terms of the rate of PVI. Short-term follow-up was evaluated by the means of 24-h Holters and clinical examinations at regular intervals. Results: Fifty-two consecutive patients (35 male (67%); mean age, 59.8±10.5) were included. Mean procedure and fluoroscopy times were 96±15 and 13.2±8.3 min, respectively. Mean time from groin puncture to catheter extraction was 60.4±20 min. After a mean of 1.5 freeze cycles per vein of 3 min in duration, all 208 (100%) PVs could be isolated with the CB-A. A total 192 (91%) veins were isolated during the first freeze. At a mean of 5.7-month follow-up, 82% of patients were free of AF. Conclusion: CB-A is effective in producing PVI by using 3-min-duration freeze cycles. After a mean of 1.5 freeze per vein, freedom from AF was achieved in 82% of patients at 6-month follow-up.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalJournal of Interventional Cardiac Electrophysiology
Volume39
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Ablation
  • Atrial fibrillation
  • Cryoballoon
  • Freeze duration
  • Pulmonary vein isolation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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