TY - JOUR
T1 - Initial prostate cancer diagnosis and disease staging - The role of choline-PET-CT
AU - Mapelli, Paola
AU - Picchio, Maria
PY - 2015/9/9
Y1 - 2015/9/9
N2 - An early and correct diagnosis together with accurate staging of prostate cancer is necessary in order to plan the most appropriate treatment strategy. Morphological imaging modalities such as transrectal ultrasonography (TRUS), CT, and MRI can have some limitations regarding their accuracy for primary diagnosis and staging of prostate cancer; for instance, they have limited specificity in differentiating cancer from benign prostatic conditions and, by using size as the only criterion to characterize lymph node metastases, they might not be accurate enough for tumour characterization. In this scenario, PET-CT with 11 C-labelled or 18 F-labelled choline derivatives provides morphological and functional characterization and could overcome the limitations of the conventional imaging techniques. PET-CT is one of the most investigated molecular imaging modalities for prostate cancer diagnosis and staging. Currently, the main investigations on the role of PET-CT in the diagnosis and staging of prostate cancer have been performed on a retrospective basis and this type of analysis might be one of the main reasons why different results regarding its diagnostic accuracy have been reported.
AB - An early and correct diagnosis together with accurate staging of prostate cancer is necessary in order to plan the most appropriate treatment strategy. Morphological imaging modalities such as transrectal ultrasonography (TRUS), CT, and MRI can have some limitations regarding their accuracy for primary diagnosis and staging of prostate cancer; for instance, they have limited specificity in differentiating cancer from benign prostatic conditions and, by using size as the only criterion to characterize lymph node metastases, they might not be accurate enough for tumour characterization. In this scenario, PET-CT with 11 C-labelled or 18 F-labelled choline derivatives provides morphological and functional characterization and could overcome the limitations of the conventional imaging techniques. PET-CT is one of the most investigated molecular imaging modalities for prostate cancer diagnosis and staging. Currently, the main investigations on the role of PET-CT in the diagnosis and staging of prostate cancer have been performed on a retrospective basis and this type of analysis might be one of the main reasons why different results regarding its diagnostic accuracy have been reported.
UR - http://www.scopus.com/inward/record.url?scp=84941191269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941191269&partnerID=8YFLogxK
U2 - 10.1038/nrurol.2015.191
DO - 10.1038/nrurol.2015.191
M3 - Article
C2 - 26260884
AN - SCOPUS:84941191269
VL - 12
SP - 510
EP - 518
JO - Nature Reviews Urology
JF - Nature Reviews Urology
SN - 1759-4812
IS - 9
ER -