Initial prostate cancer diagnosis and disease staging - The role of choline-PET-CT

Paola Mapelli, Maria Picchio

Research output: Contribution to journalArticlepeer-review


An early and correct diagnosis together with accurate staging of prostate cancer is necessary in order to plan the most appropriate treatment strategy. Morphological imaging modalities such as transrectal ultrasonography (TRUS), CT, and MRI can have some limitations regarding their accuracy for primary diagnosis and staging of prostate cancer; for instance, they have limited specificity in differentiating cancer from benign prostatic conditions and, by using size as the only criterion to characterize lymph node metastases, they might not be accurate enough for tumour characterization. In this scenario, PET-CT with 11 C-labelled or 18 F-labelled choline derivatives provides morphological and functional characterization and could overcome the limitations of the conventional imaging techniques. PET-CT is one of the most investigated molecular imaging modalities for prostate cancer diagnosis and staging. Currently, the main investigations on the role of PET-CT in the diagnosis and staging of prostate cancer have been performed on a retrospective basis and this type of analysis might be one of the main reasons why different results regarding its diagnostic accuracy have been reported.

Original languageEnglish
Pages (from-to)510-518
Number of pages9
JournalNature Reviews Urology
Issue number9
Publication statusPublished - Sep 9 2015

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Initial prostate cancer diagnosis and disease staging - The role of choline-PET-CT'. Together they form a unique fingerprint.

Cite this