Initial results from a pet/planar small animal imaging system

S. Siegel, J. J. Vaquera, L. Aloj, J. Seidel, E. Jagoda, W. R. Gandler, W. C. Eckelman, M. V. Green

Research output: Contribution to journalArticle

Abstract

A pair of stationary, opposed scintillation detectors in time coincidence is being used to create planar projection or tomographic images of small animals injected with positronemitting radiotracers. The detectors are comprised of arrays of individual crystals of bismuth germanate coupled to position-sensitive photomultiplier tubes. The system uses FERA (LeCroy Research Systems) charge-sensitive ADCs and a low cost digital I/O board as a FERA bus-to-host bridge. In projection mode, the animal is placed within the 55 mm x 45 mm useful field-of-view of the detectors and images are formed from coincidence lines that fall close to the normals of both detectors. In tomographic mode, the animal is placed on a rotation stage between the detectors and rotated around a vertical axis to acquire all possible lines-of-response. Tomographic images are then reconstructed from those lines falling within a user-specified angle of each detector normal. In mice, the system is capable of high-speed, whole-body dynamic projection imaging, and whole body tomographic imaging of slowly varying tracer distributions. An ECG gating capability is also available for evaluating cardiac function. This system is currently being used to study tracer transport in normal and genetically engineered mice.

Original languageEnglish
Pages (from-to)571-575
Number of pages5
JournalIEEE Transactions on Nuclear Science
Volume46
Issue number3 PART 2
DOIs
Publication statusPublished - 1999

Fingerprint

Imaging systems
animals
Animals
Detectors
detectors
projection
tracers
mice
Imaging techniques
Scintillation counters
Photomultipliers
Bismuth
Electrocardiography
photomultiplier tubes
falling
bismuth
scintillation
field of view
Crystals
high speed

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Siegel, S., Vaquera, J. J., Aloj, L., Seidel, J., Jagoda, E., Gandler, W. R., ... Green, M. V. (1999). Initial results from a pet/planar small animal imaging system. IEEE Transactions on Nuclear Science, 46(3 PART 2), 571-575. https://doi.org/10.1109/23.775581

Initial results from a pet/planar small animal imaging system. / Siegel, S.; Vaquera, J. J.; Aloj, L.; Seidel, J.; Jagoda, E.; Gandler, W. R.; Eckelman, W. C.; Green, M. V.

In: IEEE Transactions on Nuclear Science, Vol. 46, No. 3 PART 2, 1999, p. 571-575.

Research output: Contribution to journalArticle

Siegel, S, Vaquera, JJ, Aloj, L, Seidel, J, Jagoda, E, Gandler, WR, Eckelman, WC & Green, MV 1999, 'Initial results from a pet/planar small animal imaging system', IEEE Transactions on Nuclear Science, vol. 46, no. 3 PART 2, pp. 571-575. https://doi.org/10.1109/23.775581
Siegel, S. ; Vaquera, J. J. ; Aloj, L. ; Seidel, J. ; Jagoda, E. ; Gandler, W. R. ; Eckelman, W. C. ; Green, M. V. / Initial results from a pet/planar small animal imaging system. In: IEEE Transactions on Nuclear Science. 1999 ; Vol. 46, No. 3 PART 2. pp. 571-575.
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