Abstract
The purpose of this review is to summarize the results of reports on injectable agents in the treatment of female stress urinary incontinence. Six agents were reviewed: Teflon; autologous fat; collagen; silicone microparticles; silicone microballoons, and pyrolytic carbon. Collagen was the most frequently reported agent and yielded a 1-year cure/improvement rate of 60-80%, but results worsened significantly with longer follow-up. Teflon has been used longer in the treatment of stress incontinence, but low long- and short-term success rates and reported complications such as particle migration have prevented its widespread acceptance. Autologous fat has been suggested as a natural injectable but its success rate has been disappointing. The injection of silicone microparticles is associated with a long-term success rate of about 70% in patients with intrinsic sphincter deficiency, and it can now be injected more easily without the need of urethroscopy. Silicone microballoons and pyrolytic carbon has recently been introduced into clinical practice with a short-term success rate of about 70%, but longer follow-up is needed. In conclusion, the long-term durability, cost-effectiveness, and some safety issues still have to be addressed by further clinical trials.
| Original language | English |
|---|---|
| Pages (from-to) | 67-72 |
| Number of pages | 6 |
| Journal | Gynecologic and Obstetric Investigation |
| Volume | 54 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Intrinsic sphincter deficiency
- Periurethral injection
- Stress incontinence
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Injection therapy for the treatment of stress urinary incontinence in women. / Meschia, Michele; Pifarotti, P.; Gattei, U.; Crosignani, P. G.
In: Gynecologic and Obstetric Investigation, Vol. 54, No. 2, 2002, p. 67-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Injection therapy for the treatment of stress urinary incontinence in women
AU - Meschia, Michele
AU - Pifarotti, P.
AU - Gattei, U.
AU - Crosignani, P. G.
PY - 2002
Y1 - 2002
N2 - The purpose of this review is to summarize the results of reports on injectable agents in the treatment of female stress urinary incontinence. Six agents were reviewed: Teflon; autologous fat; collagen; silicone microparticles; silicone microballoons, and pyrolytic carbon. Collagen was the most frequently reported agent and yielded a 1-year cure/improvement rate of 60-80%, but results worsened significantly with longer follow-up. Teflon has been used longer in the treatment of stress incontinence, but low long- and short-term success rates and reported complications such as particle migration have prevented its widespread acceptance. Autologous fat has been suggested as a natural injectable but its success rate has been disappointing. The injection of silicone microparticles is associated with a long-term success rate of about 70% in patients with intrinsic sphincter deficiency, and it can now be injected more easily without the need of urethroscopy. Silicone microballoons and pyrolytic carbon has recently been introduced into clinical practice with a short-term success rate of about 70%, but longer follow-up is needed. In conclusion, the long-term durability, cost-effectiveness, and some safety issues still have to be addressed by further clinical trials.
AB - The purpose of this review is to summarize the results of reports on injectable agents in the treatment of female stress urinary incontinence. Six agents were reviewed: Teflon; autologous fat; collagen; silicone microparticles; silicone microballoons, and pyrolytic carbon. Collagen was the most frequently reported agent and yielded a 1-year cure/improvement rate of 60-80%, but results worsened significantly with longer follow-up. Teflon has been used longer in the treatment of stress incontinence, but low long- and short-term success rates and reported complications such as particle migration have prevented its widespread acceptance. Autologous fat has been suggested as a natural injectable but its success rate has been disappointing. The injection of silicone microparticles is associated with a long-term success rate of about 70% in patients with intrinsic sphincter deficiency, and it can now be injected more easily without the need of urethroscopy. Silicone microballoons and pyrolytic carbon has recently been introduced into clinical practice with a short-term success rate of about 70%, but longer follow-up is needed. In conclusion, the long-term durability, cost-effectiveness, and some safety issues still have to be addressed by further clinical trials.
KW - Intrinsic sphincter deficiency
KW - Periurethral injection
KW - Stress incontinence
UR - http://www.scopus.com/inward/record.url?scp=0036978899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036978899&partnerID=8YFLogxK
U2 - 10.1159/000067721
DO - 10.1159/000067721
M3 - Article
C2 - 12566746
AN - SCOPUS:0036978899
VL - 54
SP - 67
EP - 72
JO - Gynecologic and Obstetric Investigation
JF - Gynecologic and Obstetric Investigation
SN - 0378-7346
IS - 2
ER -