iNKT-cell help to B cells: A cooperative job between innate and adaptive immune responses

Paolo Dellabona, Sergio Abrignani, Giulia Casorati

Research output: Contribution to journalArticle

Abstract

T-cell help to B lymphocytes is one of the most important events in adaptive immune responses in health and disease. It is generally delivered by cognate CD4+ T follicular helper (TFH) cells via both cell-to-cell contacts and soluble mediators, and it is essential for both the clonal expansion of antibody (Ab)-secreting B cells and memory B-cell formation. CD1d-restricted invariant natural killer T (iNKT) cells are a subset of innate-like T lymphocytes that rapidly respond to stimulation with specific lipid antigens (Ags) that are derived from infectious pathogens or stressed host cells. Activated iNKT cells produce a wide range of cytokines and upregulate costimulatory molecules that can promote activation of dendritic cells (DCs), natural killer (NK) cells, and T cells. A decade ago, we discovered that iNKT cells can help B cells to proliferate and to produce IgG Abs in vitro and in vivo. This adjuvant-like function of Ag-activated iNKT cells provides a flexible set of helper mechanisms that expand the current paradigm of T-cell-B-cell interaction and highlights the potential of iNKT-cell targeting vaccine formulations.

Original languageEnglish
Pages (from-to)2230-2237
Number of pages8
JournalEuropean Journal of Immunology
Volume44
Issue number8
DOIs
Publication statusPublished - 2014

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Keywords

  • B-cell help
  • CD1d
  • T follicular helper cells
  • Vaccines

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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