Innate and adaptive immune response in stroke: Focus on epigenetic regulation

Antonietta Picascia, Vincenzo Grimaldi, Carmela Iannone, Andrea Soricelli, Claudio Napoli

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation and immune response play a pivotal role in the pathophysiology of ischemic stroke giving their contribution to tissue damage and repair. Emerging evidence supports the involvement of epigenetic mechanisms such as methylation, histone modification and miRNAs in the pathogenesis of stroke.Interestingly, epigenetics can influence the molecular events involved in ischemic injury by controlling the switch from pro- to anti-inflammatory response, however, this is still a field to be fully explored. The knowledge of epigenetic processes could to allow for the discovery of more sensitive and specific biomarkers for risk, onset, and progression of disease as well as further novel tools to be used in both primary prevention and therapy of stroke. Indeed, studies performed in vitro and in small animal models seem to suggest a neuroprotective role of HDAC inhibitors (e.g. valproic acid) and antagomir (e.g. anti-miR-181a) in ischemic condition by modulation of both immune and inflammatory pathways. Thus, the clinical implications of altered epigenetic mechanisms for the prevention of stroke are very promising but clinical prospective studies and translational approaches are still warranted.

Original languageEnglish
Pages (from-to)111-120
Number of pages10
JournalJournal of Neuroimmunology
Volume289
DOIs
Publication statusPublished - Dec 15 2015

Keywords

  • Antagomir
  • Epigenetics
  • HDACi
  • Innate and adaptive response
  • Stroke

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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