Abstract
Infiltration by inflammatory leukocytes is a hallmark of all forms of endometriosis. Conversely, the innate immune system plays a key role in regulating events such as cell adhesion, migration, survival and neoangiogenesis of transformed or ectopic tissue. All these features are involved, and possibly required, in the development of endometriotic lesions. Recent data suggest that infiltrating leukocytes are not a mere epiphenomenon but represent an actual requirement for the development of the disease. In this scenario, the functional plasticity of infiltrating macrophages is a key event in the origin and maintenance of endometriotic lesions: the erroneous polarization of macrophages towards cells sustaining angiogenesis and tissue remodeling represents a potential target for novel molecular therapies.
| Original language | English |
|---|---|
| Pages (from-to) | 55-62 |
| Number of pages | 8 |
| Journal | Journal of Endometriosis and Pelvic Pain Disorders |
| Volume | 2 |
| Issue number | 2 |
| Publication status | Published - Apr 2010 |
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Keywords
- Angiogenesis
- Macrophages
- Peritoneal lesions
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Innate immune cells : Gatekeepers of endometriotic lesions growth and vascularization. / Capobianco, Annalisa; Cottone, Lucia; Monno, Antonella; Ferrari, Stefano; Panina-Bordignon, Paola; Manfredi, Angelo A.; Rovere-Querini, Patrizia.
In: Journal of Endometriosis and Pelvic Pain Disorders, Vol. 2, No. 2, 04.2010, p. 55-62.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Innate immune cells
T2 - Gatekeepers of endometriotic lesions growth and vascularization
AU - Capobianco, Annalisa
AU - Cottone, Lucia
AU - Monno, Antonella
AU - Ferrari, Stefano
AU - Panina-Bordignon, Paola
AU - Manfredi, Angelo A.
AU - Rovere-Querini, Patrizia
PY - 2010/4
Y1 - 2010/4
N2 - Infiltration by inflammatory leukocytes is a hallmark of all forms of endometriosis. Conversely, the innate immune system plays a key role in regulating events such as cell adhesion, migration, survival and neoangiogenesis of transformed or ectopic tissue. All these features are involved, and possibly required, in the development of endometriotic lesions. Recent data suggest that infiltrating leukocytes are not a mere epiphenomenon but represent an actual requirement for the development of the disease. In this scenario, the functional plasticity of infiltrating macrophages is a key event in the origin and maintenance of endometriotic lesions: the erroneous polarization of macrophages towards cells sustaining angiogenesis and tissue remodeling represents a potential target for novel molecular therapies.
AB - Infiltration by inflammatory leukocytes is a hallmark of all forms of endometriosis. Conversely, the innate immune system plays a key role in regulating events such as cell adhesion, migration, survival and neoangiogenesis of transformed or ectopic tissue. All these features are involved, and possibly required, in the development of endometriotic lesions. Recent data suggest that infiltrating leukocytes are not a mere epiphenomenon but represent an actual requirement for the development of the disease. In this scenario, the functional plasticity of infiltrating macrophages is a key event in the origin and maintenance of endometriotic lesions: the erroneous polarization of macrophages towards cells sustaining angiogenesis and tissue remodeling represents a potential target for novel molecular therapies.
KW - Angiogenesis
KW - Macrophages
KW - Peritoneal lesions
UR - http://www.scopus.com/inward/record.url?scp=77953999139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953999139&partnerID=8YFLogxK
M3 - Article
VL - 2
SP - 55
EP - 62
JO - Journal of Endometriosis
JF - Journal of Endometriosis
SN - 2035-9969
IS - 2
ER -