Innate immune cells: Gatekeepers of endometriotic lesions growth and vascularization

Annalisa Capobianco, Lucia Cottone, Antonella Monno, Stefano Ferrari, Paola Panina-Bordignon, Angelo A. Manfredi, Patrizia Rovere-Querini

Research output: Contribution to journalArticle

Abstract

Infiltration by inflammatory leukocytes is a hallmark of all forms of endometriosis. Conversely, the innate immune system plays a key role in regulating events such as cell adhesion, migration, survival and neoangiogenesis of transformed or ectopic tissue. All these features are involved, and possibly required, in the development of endometriotic lesions. Recent data suggest that infiltrating leukocytes are not a mere epiphenomenon but represent an actual requirement for the development of the disease. In this scenario, the functional plasticity of infiltrating macrophages is a key event in the origin and maintenance of endometriotic lesions: the erroneous polarization of macrophages towards cells sustaining angiogenesis and tissue remodeling represents a potential target for novel molecular therapies.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalJournal of Endometriosis and Pelvic Pain Disorders
Volume2
Issue number2
Publication statusPublished - Apr 2010

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Keywords

  • Angiogenesis
  • Macrophages
  • Peritoneal lesions

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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