Abstract
Biofilm has been recognized as a well-protected form of living for bacteria, contributing to bacterial pathogenicity, particularly for opportunistic species. Biofilm-associated infections are marked by their persistence. Extensive research has been devoted to the formation and composition of biofilms. The immune response against biofilms remains rather unexplored, but there is the notion that bacteria within a biofilm are protected from host defences. Here we glance at the mechanisms by which neutrophils recognize and face biofilms in implant infections and discuss the implications of this interplay, as well as speculate on its significance.
| Original language | English |
|---|---|
| Article number | 387 |
| Journal | Materials |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Biofilm
- GroEL
- Implant infections
- Innate immune response
- Neutrophils
- Orthopedics
- Staphylococcus
ASJC Scopus subject areas
- Materials Science(all)
Cite this
Innate immune response in implant-associated infections : Neutrophils against Biofilms. / Dapunt, Ulrike; Hänsch, Gertrud Maria; Arciola, Carla Renata.
In: Materials, Vol. 9, No. 5, 387, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Innate immune response in implant-associated infections
T2 - Neutrophils against Biofilms
AU - Dapunt, Ulrike
AU - Hänsch, Gertrud Maria
AU - Arciola, Carla Renata
PY - 2016
Y1 - 2016
N2 - Biofilm has been recognized as a well-protected form of living for bacteria, contributing to bacterial pathogenicity, particularly for opportunistic species. Biofilm-associated infections are marked by their persistence. Extensive research has been devoted to the formation and composition of biofilms. The immune response against biofilms remains rather unexplored, but there is the notion that bacteria within a biofilm are protected from host defences. Here we glance at the mechanisms by which neutrophils recognize and face biofilms in implant infections and discuss the implications of this interplay, as well as speculate on its significance.
AB - Biofilm has been recognized as a well-protected form of living for bacteria, contributing to bacterial pathogenicity, particularly for opportunistic species. Biofilm-associated infections are marked by their persistence. Extensive research has been devoted to the formation and composition of biofilms. The immune response against biofilms remains rather unexplored, but there is the notion that bacteria within a biofilm are protected from host defences. Here we glance at the mechanisms by which neutrophils recognize and face biofilms in implant infections and discuss the implications of this interplay, as well as speculate on its significance.
KW - Biofilm
KW - GroEL
KW - Implant infections
KW - Innate immune response
KW - Neutrophils
KW - Orthopedics
KW - Staphylococcus
UR - http://www.scopus.com/inward/record.url?scp=84969963445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969963445&partnerID=8YFLogxK
U2 - 10.3390/ma9050387
DO - 10.3390/ma9050387
M3 - Article
AN - SCOPUS:84969963445
VL - 9
JO - Materials
JF - Materials
SN - 1996-1944
IS - 5
M1 - 387
ER -