Inner ester derivatives of gangliosides protect autonomic nerves of alloxan-diabetic rats against Na+, K+-ATPase activity defects

R. Bianchi, C. Triban, P. Marini, B. Figliomeni, M. Paro, G. Italiano, M. Prosdocimi, M. G. Fiori

Research output: Contribution to journalArticle

Abstract

Bovine brain gangliosides have been shown to prevent decay in Na+,K+-ATPase activity in sciatic and optic nerves of alloxan- and streptozotocin-diabetic rats. In the search for a drug with greater bioavailability and increased incorporation into neural tissue, ganglioside inner ester derivatives (AGF1) were recently developed. We evaluated the effect of AGF1 treatment on Na+,K+-ATPase activity in homogenates of vagus nerve from alloxan-diabetic rats (100 mg/kg s.c.). Animals were treated with AGF1: 10 mg/kg 6 days/week i.p., or 30 mg/kg biweekly i.p. Treatment began 10 d post-alloxan and continued for 8 consecutive weeks. Normal age- and sex-matched rats were used as controls. Alloxan intoxication produced a 39% decrease in Na+,K+-ATPase activity of the vagus nerve, which was completely restored (96-97% recovery) by both AGF1 regimes. Results suggest that ganglioside inner ester derivatives may be used in the clinical setting for the management of diabetic autonomic neuropathy.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalDiabetes Research and Clinical Practice
Volume12
Issue number2
DOIs
Publication statusPublished - 1991

Keywords

  • Alloxan-induced diabetic neuropathy
  • Ganglioside inner ester derivative
  • Na, K-ATPase
  • Rat vagus nerve

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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