TY - JOUR
T1 - Innovations, challenges, and minimal information for standardization of humanized mice
AU - Stripecke, Renata
AU - Münz, Christian
AU - Schuringa, Jan Jacob
AU - Bissig, Karl-Dimiter
AU - Soper, Brian
AU - Meeham, Terrence
AU - Yao, Li-Chin
AU - Di Santo, James P
AU - Brehm, Michael
AU - Rodriguez, Estefania
AU - Wege, Anja Kathrin
AU - Bonnet, Dominique
AU - Guionaud, Silvia
AU - Howard, Kristina E
AU - Kitchen, Scott
AU - Klein, Florian
AU - Saeb-Parsy, Kourosh
AU - Sam, Johannes
AU - Sharma, Amar Deep
AU - Trumpp, Andreas
AU - Trusolino, Livio
AU - Bult, Carol
AU - Shultz, Leonard
N1 - © 2020 The Authors. Published under the terms of the CC BY 4.0 license.
PY - 2020/7/7
Y1 - 2020/7/7
N2 - Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community-driven resource called "Minimal Information for Standardization of Humanized Mice" (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. Within MISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.
AB - Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community-driven resource called "Minimal Information for Standardization of Humanized Mice" (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. Within MISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.
U2 - 10.15252/emmm.201708662
DO - 10.15252/emmm.201708662
M3 - Review article
C2 - 32578942
VL - 12
SP - e8662
JO - EMBO Molecular Medicine
JF - EMBO Molecular Medicine
SN - 1757-4676
IS - 7
ER -