Innovative Biomaterials for Bone Regrowth

Maria Rosa Iaquinta, Elisa Mazzoni, Marco Manfrini, Antonio D'Agostino, Lorenzo Trevisiol, Riccardo Nocini, Leonardo Trombelli, Giovanni Barbanti-Brodano, Fernanda Martini, Mauro Tognon

Research output: Contribution to journalReview article

Abstract

The regenerative medicine, a new discipline that merges biological sciences and the fundamental of engineering to develop biological substitutes, has greatly benefited from recent advances in the material engineering and the role of stem cells in tissue regeneration. Regenerative medicine strategies, involving the combination of biomaterials/scaffolds, cells, and bioactive agents, have been of great interest especially for the repair of damaged bone and bone regrowth. In the last few years, the life expectancy of our population has progressively increased. Aging has highlighted the need for intervention on human bone with biocompatible materials that show high performance for the regeneration of the bone, efficiently and in a short time. In this review, the different aspects of tissue engineering applied to bone engineering were taken into consideration. The first part of this review introduces the bone cellular biology/molecular genetics. Data on biomaterials, stem cells, and specific growth factors for the bone regrowth are reported in this review.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume20
Issue number3
DOIs
Publication statusPublished - Jan 31 2019

Keywords

  • biomaterial
  • bone
  • growth factors
  • regenerative medicine
  • stem cells

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    Iaquinta, M. R., Mazzoni, E., Manfrini, M., D'Agostino, A., Trevisiol, L., Nocini, R., Trombelli, L., Barbanti-Brodano, G., Martini, F., & Tognon, M. (2019). Innovative Biomaterials for Bone Regrowth. International Journal of Molecular Sciences, 20(3), 1-17. https://doi.org/10.3390/ijms20030618