Innovative quantitative testing of hand function in Charcot-Marie-Tooth neuropathy

Maria A. Alberti, Laura Mori, Luca Francini, Ilaria Poggi, Margherita Monti Bragadin, Emilia Bellone, Marina Grandis, Giovanni Maggi, Lizia Reni, Maria P. Sormani, Andrea Tacchino, Luca Padua, Valeria Prada, Marco Bove, Angelo Schenone

Research output: Contribution to journalArticle

Abstract

To describe a new test to quantitatively evaluate hand function in patients affected by Charcot-Marie-Tooth neuropathy (CMT). The sensor-engineered glove test (SEGT) was applied to CMT patients (N: 26) and compared with a cohort of healthy controls (HC, N: 26). CMT patients were further divided into subjects with clinically normal (group 1) or impaired hand (group 2) function. The SEGT parameters evaluated were touch duration, inter-tapping interval, and movement rate parameters of two different sequences: finger tapping (FT) and index-medium-ring-little (IMRL) performed at self-paced mode (SPM) and maximum velocity (MV). Hand function and strength were assessed by the 9-hole peg test (9HPT) and dynamometry. Disability of patients was measured by the CMT neuropathy score. CMT patients had significantly worst performances at SEGT than controls regarding the rate of execution of both FT (at MV) and IMRL sequences (at SPM and MV). The rate parameter at MV in IMRL sequence showed a significant trend of decreasing in its average between HC (n: 26, rate = 3.08 ± 0.52 Hz), group 1 (n: 9, rate = 2.64 ± 0.66 Hz) and group 2 (n: 17, rate = 2.19 ± 0.45 Hz) (p for trend

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalJournal of the Peripheral Nervous System
Volume20
Issue number4
DOIs
Publication statusPublished - Dec 1 2015

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Tooth
Hand
Fingers
Touch
Hand Strength

Keywords

  • Charcot-Marie-Tooth
  • CMT
  • hand dexterity
  • hand strength
  • sensory-engineered glove test

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Alberti, M. A., Mori, L., Francini, L., Poggi, I., Monti Bragadin, M., Bellone, E., ... Schenone, A. (2015). Innovative quantitative testing of hand function in Charcot-Marie-Tooth neuropathy. Journal of the Peripheral Nervous System, 20(4), 410-414. https://doi.org/10.1111/jns.12150

Innovative quantitative testing of hand function in Charcot-Marie-Tooth neuropathy. / Alberti, Maria A.; Mori, Laura; Francini, Luca; Poggi, Ilaria; Monti Bragadin, Margherita; Bellone, Emilia; Grandis, Marina; Maggi, Giovanni; Reni, Lizia; Sormani, Maria P.; Tacchino, Andrea; Padua, Luca; Prada, Valeria; Bove, Marco; Schenone, Angelo.

In: Journal of the Peripheral Nervous System, Vol. 20, No. 4, 01.12.2015, p. 410-414.

Research output: Contribution to journalArticle

Alberti, MA, Mori, L, Francini, L, Poggi, I, Monti Bragadin, M, Bellone, E, Grandis, M, Maggi, G, Reni, L, Sormani, MP, Tacchino, A, Padua, L, Prada, V, Bove, M & Schenone, A 2015, 'Innovative quantitative testing of hand function in Charcot-Marie-Tooth neuropathy', Journal of the Peripheral Nervous System, vol. 20, no. 4, pp. 410-414. https://doi.org/10.1111/jns.12150
Alberti MA, Mori L, Francini L, Poggi I, Monti Bragadin M, Bellone E et al. Innovative quantitative testing of hand function in Charcot-Marie-Tooth neuropathy. Journal of the Peripheral Nervous System. 2015 Dec 1;20(4):410-414. https://doi.org/10.1111/jns.12150
Alberti, Maria A. ; Mori, Laura ; Francini, Luca ; Poggi, Ilaria ; Monti Bragadin, Margherita ; Bellone, Emilia ; Grandis, Marina ; Maggi, Giovanni ; Reni, Lizia ; Sormani, Maria P. ; Tacchino, Andrea ; Padua, Luca ; Prada, Valeria ; Bove, Marco ; Schenone, Angelo. / Innovative quantitative testing of hand function in Charcot-Marie-Tooth neuropathy. In: Journal of the Peripheral Nervous System. 2015 ; Vol. 20, No. 4. pp. 410-414.
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