Abstract
Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.
| Original language | English |
|---|---|
| Pages (from-to) | 289-294 |
| Number of pages | 6 |
| Journal | Italian Journal of Biochemistry |
| Volume | 40 |
| Issue number | 5 |
| Publication status | Published - Sep 1991 |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Copani, A., Raciti, G., Bruno, V., Sortino, M. A., Nicoletti, F., Canonico, P. L., & Cambria, A. (1991). Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver. Italian Journal of Biochemistry, 40(5), 289-294.