Abstract
Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.
| Original language | English |
|---|---|
| Pages (from-to) | 289-294 |
| Number of pages | 6 |
| Journal | Italian Journal of Biochemistry |
| Volume | 40 |
| Issue number | 5 |
| Publication status | Published - Sep 1991 |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver. / Copani, A.; Raciti, G.; Bruno, V.; Sortino, M. A.; Nicoletti, F.; Canonico, P. L.; Cambria, A.
In: Italian Journal of Biochemistry, Vol. 40, No. 5, 09.1991, p. 289-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.
AU - Copani, A.
AU - Raciti, G.
AU - Bruno, V.
AU - Sortino, M. A.
AU - Nicoletti, F.
AU - Canonico, P. L.
AU - Cambria, A.
PY - 1991/9
Y1 - 1991/9
N2 - Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.
AB - Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.
UR - http://www.scopus.com/inward/record.url?scp=0026212638&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026212638&partnerID=8YFLogxK
M3 - Article
VL - 40
SP - 289
EP - 294
JO - Italian Journal of Biochemistry
JF - Italian Journal of Biochemistry
SN - 0021-2938
IS - 5
ER -