Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

A. Copani, G. Raciti, V. Bruno, M. A. Sortino, F. Nicoletti, P. L. Canonico, A. Cambria

Research output: Contribution to journalArticle

Abstract

Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalItalian Journal of Biochemistry
Volume40
Issue number5
Publication statusPublished - Sep 1991

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ASJC Scopus subject areas

  • Biochemistry

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