Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

A. Copani, G. Raciti, V. Bruno, M. A. Sortino, F. Nicoletti, P. L. Canonico, A. Cambria

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalItalian Journal of Biochemistry
Volume40
Issue number5
Publication statusPublished - Sep 1991

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Phytic Acid
Mitochondria
Liver Mitochondrion
Liver
Rats
Homeostasis
Membranes
Molecules

ASJC Scopus subject areas

  • Biochemistry

Cite this

Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver. / Copani, A.; Raciti, G.; Bruno, V.; Sortino, M. A.; Nicoletti, F.; Canonico, P. L.; Cambria, A.

In: Italian Journal of Biochemistry, Vol. 40, No. 5, 09.1991, p. 289-294.

Research output: Contribution to journalArticle

Copani, A, Raciti, G, Bruno, V, Sortino, MA, Nicoletti, F, Canonico, PL & Cambria, A 1991, 'Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.', Italian Journal of Biochemistry, vol. 40, no. 5, pp. 289-294.
Copani, A. ; Raciti, G. ; Bruno, V. ; Sortino, M. A. ; Nicoletti, F. ; Canonico, P. L. ; Cambria, A. / Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver. In: Italian Journal of Biochemistry. 1991 ; Vol. 40, No. 5. pp. 289-294.
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