Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

A. Copani; G. Raciti; V. Bruno; M. A. Sortino; F. Nicoletti; P. L. Canonico; A. Cambria

Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

A. Copani, G. Raciti, V. Bruno, M. A. Sortino, F. Nicoletti, P. L. Canonico, A. Cambria

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Abstract

Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

Original language	English
Pages (from-to)	289-294
Number of pages	6
Journal	Italian Journal of Biochemistry
Volume	40
Issue number	5
Publication status	Published - Sep 1991

ASJC Scopus subject areas

Biochemistry

Cite this

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title = "Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.",

abstract = "Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.",

author = "A. Copani and G. Raciti and V. Bruno and Sortino, {M. A.} and F. Nicoletti and Canonico, {P. L.} and A. Cambria",

year = "1991",

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language = "English",

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pages = "289--294",

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T1 - Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

AU - Copani, A.

AU - Raciti, G.

AU - Bruno, V.

AU - Sortino, M. A.

AU - Nicoletti, F.

AU - Canonico, P. L.

AU - Cambria, A.

PY - 1991/9

Y1 - 1991/9

N2 - Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

AB - Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

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AN - SCOPUS:0026212638

VL - 40

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JO - Italian Journal of Biochemistry

JF - Italian Journal of Biochemistry

SN - 0021-2938

IS - 5

ER -

Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

Abstract

ASJC Scopus subject areas

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