Inositol hexakisphosphate stimulus 45Ca2+ uptake in anterior pituitary cells in culture

Maria Angela Sortino, Ferdinando Nicoletti, Pier Luigi Canonico

Research output: Contribution to journalArticlepeer-review

Abstract

Inositol hexakisphosphate (InsP6) is thought to act as an intercellular signal molecule in the central nervous system. We report that InsP6 stimulates 45Ca2+ uptake in cultured anterior pituitary cells. This effect is concentration-dependent is mimicked by inositolpentakis phosphate (InsP5) but not by inositoltetrakis phosphate (InsP4), is present after 2 min of incubation, is independent of extracellular Na+ and insensitive to nifedipine and verapamil. These results suggest that InsP6, a putative metabolite of the inositol cycle, may regulate transmembrane mechanism in the pituitary.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume189
Issue number1
DOIs
Publication statusPublished - Jul 31 1990

Keywords

  • Ca
  • InsP
  • Pituitary

ASJC Scopus subject areas

  • Pharmacology

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