Inositol hexakisphosphate (InsP6) is thought to act as an intercellular signal molecule in the central nervous system. We report that InsP6 stimulates 45Ca2+ uptake in cultured anterior pituitary cells. This effect is concentration-dependent is mimicked by inositolpentakis phosphate (InsP5) but not by inositoltetrakis phosphate (InsP4), is present after 2 min of incubation, is independent of extracellular Na+ and insensitive to nifedipine and verapamil. These results suggest that InsP6, a putative metabolite of the inositol cycle, may regulate transmembrane mechanism in the pituitary.
|Number of pages||4|
|Journal||European Journal of Pharmacology: Molecular Pharmacology|
|Publication status||Published - Jul 31 1990|
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