Inositol-specific phospholipase C in low and fast proliferating hepatoma cell lines.

P. Santi, L. Solimando, N. Zini, S. Santi, M. Riccio, L. Guidotti

Research output: Contribution to journalArticlepeer-review

Abstract

Inositol lipid cycle, among the pletora of signalling events, is directly involved in cell growth. It is located both in the cytoplasm and in the nucleus. Disturbances may cause uncontrolled proliferation of the cell and ultimately cancer. The phosphatidyl inositol phospolipase C (PLC) is a key enzyme in the hydrolysis of polyphosphoinositides (PIs) and could be differently involved in the normal and pathological cell growth. We report immunochemical and immunocytochemical demonstrations that the PLC isoforms are present in both cytoplasmic and nuclear compartments of low and fast proliferating hepatoma cells. The PLC activity is increased in fast proliferating cells, in which PLC delta1 and to a greater extent PLC delta4 are more expressed at cytosolic level, suggesting an involvement of PI specific PLCs in the progression of cell cycle and in the control of cell proliferation and possibly of neoplastic cell growth.

Original languageEnglish
Pages (from-to)1147-1153
Number of pages7
JournalInternational Journal of Oncology
Volume22
Issue number5
Publication statusPublished - May 2003

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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