TY - JOUR
T1 - INSIDE project
T2 - Individual air pollution exposure, extracellular vesicles signaling and hypertensive disorder development in pregnancy
AU - Ferrari, Luca
AU - Borghi, Francesca
AU - Iodice, Simona
AU - Catelan, Dolores
AU - Rossi, Stefano
AU - Giusti, Ilaria
AU - Grisotto, Laura
AU - Rovelli, Sabrina
AU - Spinazzè, Andrea
AU - Alinovi, Rossella
AU - Pinelli, Silvana
AU - Cantone, Laura
AU - Dioni, Laura
AU - Ischia, Benedetta
AU - Rota, Irene
AU - Mariani, Jacopo
AU - Rota, Federica
AU - Hoxha, Mirjam
AU - Stoppa, Giorgia
AU - Monticelli, Damiano
AU - Cavallo, Domenico
AU - Bergamaschi, Enrico
AU - Vicenzi, Marco
AU - Persico, Nicola
AU - Biggeri, Annibale
AU - Cattaneo, Andrea
AU - Dolo, Vincenza
AU - Miragoli, Michele
AU - Mozzoni, Paola
AU - Bollati, Valentina
N1 - Funding Information:
Funding: The study was funded by the governmental funding program of the Italian Ministry of Education, University, and Research “Progetti di Rilevante Interesse Nazionale” (PRIN) PRIN 0152T74ZL_004 to the INSIDE consortium (V.B., V.D., A.C., P.M., A.B.). The funder did not take part in the study design.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Hypertensive disorders are common complications during pregnancy (HDP) with substantial public health impact. Acute and chronic particulate matter (PM) exposure during pregnancy increases the risk of HDP, although the underlying molecular mechanisms remain unclear. Extracellular vesicles (EVs) may be the ideal candidates for mediating the effects of PM exposure in pregnancy as they are released in response to environmental stimuli. The INSIDE project aims to investigate this mechanism in pregnancy outcomes. The study population is enrolled at the Fetal Medicine Unit of Fondazione IRCCS Ca’Granda—Ospedale Maggiore Policlinico at 10–14 weeks of gestation. Exposure to PM10 and PM2.5 is assessed using the flexible air quality regional model (FARM) and Bayesian geostatistical models. Each woman provides a blood sample for EV analysis and circulating biomarker assessment. Moreover, a subgroup of recruited women (n = 85) is asked to participate in a cardiovascular screening program including a standard clinical evaluation, a non-invasive assessment of right ventricular function, and pulmonary circulation at rest and during exercise. These subjects are also asked to wear a personal particulate sampler, to measure PM10, PM2.5, and PM1. The INSIDE study is expected to identify the health impacts of PM exposure on pregnancy outcomes.
AB - Hypertensive disorders are common complications during pregnancy (HDP) with substantial public health impact. Acute and chronic particulate matter (PM) exposure during pregnancy increases the risk of HDP, although the underlying molecular mechanisms remain unclear. Extracellular vesicles (EVs) may be the ideal candidates for mediating the effects of PM exposure in pregnancy as they are released in response to environmental stimuli. The INSIDE project aims to investigate this mechanism in pregnancy outcomes. The study population is enrolled at the Fetal Medicine Unit of Fondazione IRCCS Ca’Granda—Ospedale Maggiore Policlinico at 10–14 weeks of gestation. Exposure to PM10 and PM2.5 is assessed using the flexible air quality regional model (FARM) and Bayesian geostatistical models. Each woman provides a blood sample for EV analysis and circulating biomarker assessment. Moreover, a subgroup of recruited women (n = 85) is asked to participate in a cardiovascular screening program including a standard clinical evaluation, a non-invasive assessment of right ventricular function, and pulmonary circulation at rest and during exercise. These subjects are also asked to wear a personal particulate sampler, to measure PM10, PM2.5, and PM1. The INSIDE study is expected to identify the health impacts of PM exposure on pregnancy outcomes.
KW - Air pollution exposure
KW - Extracellular vesicles
KW - Hypertensive disorder development
KW - Pregnancy
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U2 - 10.3390/ijerph17239046
DO - 10.3390/ijerph17239046
M3 - Article
AN - SCOPUS:85097319870
VL - 17
SP - 1
EP - 14
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 23
M1 - 9046
ER -