TY - JOUR
T1 - Inside ST-elevation myocardial infarction by monitoring concentrations of cardiovascular risk biomarkers in blood
AU - Ferraro, Simona
AU - Ardoino, Ilaria
AU - Boracchi, Patrizia
AU - Santagostino, Matteo
AU - Ciardi, Laura
AU - Antonini, Giuseppina
AU - Braga, Federica
AU - Biganzoli, Elia
AU - Panteghini, Mauro
AU - Bongo, Angelo S.
PY - 2012/5/18
Y1 - 2012/5/18
N2 - Background: No information is available on the optimal sampling time to catch the highest increase for biomarkers whose elevation after ST-elevation myocardial infarction (STEMI) is prognostic for adverse events. This study aimed to investigate release kinetics and peak times of cardiac troponin I (cTnI), C-reactive protein (CRP), B-type natriuretic peptide (BNP), chromogranin A (CgA) and cystatin C (CyC) in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Methods: Blood concentrations of cTnI, CRP, BNP, CgA and CyC were measured before and 6. h, 24. h, and 48. h after PPCI in 84 STEMI patients. The averaged trajectory of marker kinetics was estimated by multivariable regression models adjusted for patient characteristics and orthogonal polynomials were used to describe related releases. Results: From the estimated kinetics cTnI peaked at 10. h from symptoms, BNP at 28. h and CRP within 30. h. CyC concentrations did not change, whereas CgA concentrations increased from 6 to 48. h after PPCI. The amount of BNP release was found to be affected by the interaction between gender and age: females <75 years had BNP concentrations fourfold higher than males. Conclusions: According to different release kinetics a single blood sampling for measuring all biomarkers is not recommended.
AB - Background: No information is available on the optimal sampling time to catch the highest increase for biomarkers whose elevation after ST-elevation myocardial infarction (STEMI) is prognostic for adverse events. This study aimed to investigate release kinetics and peak times of cardiac troponin I (cTnI), C-reactive protein (CRP), B-type natriuretic peptide (BNP), chromogranin A (CgA) and cystatin C (CyC) in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Methods: Blood concentrations of cTnI, CRP, BNP, CgA and CyC were measured before and 6. h, 24. h, and 48. h after PPCI in 84 STEMI patients. The averaged trajectory of marker kinetics was estimated by multivariable regression models adjusted for patient characteristics and orthogonal polynomials were used to describe related releases. Results: From the estimated kinetics cTnI peaked at 10. h from symptoms, BNP at 28. h and CRP within 30. h. CyC concentrations did not change, whereas CgA concentrations increased from 6 to 48. h after PPCI. The amount of BNP release was found to be affected by the interaction between gender and age: females <75 years had BNP concentrations fourfold higher than males. Conclusions: According to different release kinetics a single blood sampling for measuring all biomarkers is not recommended.
KW - Biomarker
KW - Interaction
KW - Kinetic
KW - Serum
KW - ST-elevation myocardial infarction
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U2 - 10.1016/j.cca.2012.01.034
DO - 10.1016/j.cca.2012.01.034
M3 - Article
C2 - 22333672
AN - SCOPUS:84858618452
VL - 413
SP - 888
EP - 893
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 9-10
ER -