Abstract
Purpose: AV-45 amyloid biomarker is known to show uptake in white matter in patients with Alzheimer's disease (AD), but also in the healthy population. This binding, thought to be of a non-specific lipophilic nature, has not yet been investigated. The aim of this study was to determine the differential pattern of AV-45 binding in white matter in healthy and pathological populations. Methods: We recruited 24 patients presenting with AD at an early stage and 17 matched, healthy subjects. We used an optimized positron emission tomography-magnetic resonance imaging (PET-MRI) registration method and an approach based on an intensity histogram using several indices. We compared the results of the intensity histogram analyses with a more canonical approach based on target-to-cerebellum Standard Uptake Value (SUVr) in white and grey matter using MANOVA and discriminant analyses. A cluster analysis on white and grey matter histograms was also performed. Results: White matter histogram analysis revealed significant differences between AD and healthy subjects, which were not revealed by SUVr analysis. However, white matter histograms were not decisive to discriminate groups, and indices based on grey matter only showed better discriminative power than SUVr. The cluster analysis divided our sample into two clusters, showing different uptakes in grey, but also in white matter. Conclusion: These results demonstrate that AV-45 binding in white matter conveys subtle information not detectable using the SUVr approach. Although it is not more efficient than standard SUVr in discriminating AD patients from healthy subjects, this information could reveal white matter modifications.
| Original language | English |
|---|---|
| Pages (from-to) | 1408-1418 |
| Number of pages | 11 |
| Journal | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume | 41 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Alzheimer's disease
- Amyloid
- AV-45
- Discrimination analysis
- Intensity histogram
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Medicine(all)
Cite this
Insight on AV-45 binding in white and grey matter from histogram analysis : A study on early Alzheimer's disease patients and healthy subjects. / Nemmi, Federico; Saint-Aubert, Laure; Adel, Djilali; Salabert, Anne Sophie; Pariente, Jérémie; Barbeau, Emmanuel J.; Payoux, Pierre; Péran, Patrice.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 41, No. 7, 2014, p. 1408-1418.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insight on AV-45 binding in white and grey matter from histogram analysis
T2 - A study on early Alzheimer's disease patients and healthy subjects
AU - Nemmi, Federico
AU - Saint-Aubert, Laure
AU - Adel, Djilali
AU - Salabert, Anne Sophie
AU - Pariente, Jérémie
AU - Barbeau, Emmanuel J.
AU - Payoux, Pierre
AU - Péran, Patrice
PY - 2014
Y1 - 2014
N2 - Purpose: AV-45 amyloid biomarker is known to show uptake in white matter in patients with Alzheimer's disease (AD), but also in the healthy population. This binding, thought to be of a non-specific lipophilic nature, has not yet been investigated. The aim of this study was to determine the differential pattern of AV-45 binding in white matter in healthy and pathological populations. Methods: We recruited 24 patients presenting with AD at an early stage and 17 matched, healthy subjects. We used an optimized positron emission tomography-magnetic resonance imaging (PET-MRI) registration method and an approach based on an intensity histogram using several indices. We compared the results of the intensity histogram analyses with a more canonical approach based on target-to-cerebellum Standard Uptake Value (SUVr) in white and grey matter using MANOVA and discriminant analyses. A cluster analysis on white and grey matter histograms was also performed. Results: White matter histogram analysis revealed significant differences between AD and healthy subjects, which were not revealed by SUVr analysis. However, white matter histograms were not decisive to discriminate groups, and indices based on grey matter only showed better discriminative power than SUVr. The cluster analysis divided our sample into two clusters, showing different uptakes in grey, but also in white matter. Conclusion: These results demonstrate that AV-45 binding in white matter conveys subtle information not detectable using the SUVr approach. Although it is not more efficient than standard SUVr in discriminating AD patients from healthy subjects, this information could reveal white matter modifications.
AB - Purpose: AV-45 amyloid biomarker is known to show uptake in white matter in patients with Alzheimer's disease (AD), but also in the healthy population. This binding, thought to be of a non-specific lipophilic nature, has not yet been investigated. The aim of this study was to determine the differential pattern of AV-45 binding in white matter in healthy and pathological populations. Methods: We recruited 24 patients presenting with AD at an early stage and 17 matched, healthy subjects. We used an optimized positron emission tomography-magnetic resonance imaging (PET-MRI) registration method and an approach based on an intensity histogram using several indices. We compared the results of the intensity histogram analyses with a more canonical approach based on target-to-cerebellum Standard Uptake Value (SUVr) in white and grey matter using MANOVA and discriminant analyses. A cluster analysis on white and grey matter histograms was also performed. Results: White matter histogram analysis revealed significant differences between AD and healthy subjects, which were not revealed by SUVr analysis. However, white matter histograms were not decisive to discriminate groups, and indices based on grey matter only showed better discriminative power than SUVr. The cluster analysis divided our sample into two clusters, showing different uptakes in grey, but also in white matter. Conclusion: These results demonstrate that AV-45 binding in white matter conveys subtle information not detectable using the SUVr approach. Although it is not more efficient than standard SUVr in discriminating AD patients from healthy subjects, this information could reveal white matter modifications.
KW - Alzheimer's disease
KW - Amyloid
KW - AV-45
KW - Discrimination analysis
KW - Intensity histogram
UR - http://www.scopus.com/inward/record.url?scp=84903707993&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903707993&partnerID=8YFLogxK
U2 - 10.1007/s00259-014-2728-4
DO - 10.1007/s00259-014-2728-4
M3 - Article
C2 - 24573658
AN - SCOPUS:84903707993
VL - 41
SP - 1408
EP - 1418
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 7
ER -