Insights into defibrotide: An updated review

F. Morabito, M. Gentile, F. Gay, S. Bringhen, C. Mazzone, E. Vigna, P. Musto, F. Di Raimondo, A. Palumbo

Research output: Contribution to journalArticlepeer-review

Abstract

Defibrotide is a polydisperse oligonucleotide with antiatherosclerotic, anti-inflammatory, anti-ischaemic, pro-fibrinolytic and antithrombotic actions without significant systemic anticoagulant effects. It has been used in the treatment of various cardiovascular disorders, and especially in endothelial complications of allogeneic stem-cell transplantation. We reviewed the published work for the mechanism of action and clinical use of defibrotide to consolidate data and to describe new applications of this drug. We reviewed the most relevant papers on defibrotide published from November 1982 to January 2008. (selected through PubMed), and used recent meeting abstracts as sources for this review. Reports have suggested that defibrotide has clinical efficacy for treatment and prophylaxis of hepatic sinusoidal obstruction syndrome occurring after stem-cell transplantation. Animal models have clearly shown the potential antineoplastic effect of this drug. Further clinical investigations are needed to clarify this new application.

Original languageEnglish
Pages (from-to)763-772
Number of pages10
JournalExpert Opinion on Biological Therapy
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Angiogenesis
  • Defibrotide
  • Endothelium
  • Neoplasia
  • Sinusoidal obstruction syndrome

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Drug Discovery
  • Pharmacology

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