Insights into the clinical management of carbapenem-resistant Gram-negative infections: An Italian retrospective clinical chart review

Guido Granata, Davide Manissero, Maria Vittoria Oppia, Keiko Tone, Bin Cai, Christopher Longshaw, Carolina Venditti, Nicola Petrosillo

Research output: Contribution to journalReview articlepeer-review

Abstract

There is a lack of consensus regarding management of infections with carbapenem-resistant Gram-negative (CR-GN) pathogens. This study comprised a medical chart review to assess patient management in a high CR prevalence setting. Data was collated retrospectively from medical records of patients hospitalized between November 1st, 2015 and October 31st, 2016. Of 29 patients, 66% had respiratory tract infections. Median duration of hospitalization was 28 days and ~50% of patients were admitted to the intensive care unit, with 77% remaining for >2 weeks. Median time to obtain respiratory culture results was 5 days. Isolation of patients with diagnosed CR-GN infection took ≥5 days in >50% of patients. A majority (76%) of patients received ≥1 antibiotic before providing a specimen for culture; a total of 17 antibiotic treatments were used. Overall, 72% of patients, and 68% of those with respiratory infections, were discharged alive; 38% were discharged without further antibiotics. The difficulties in achieving effective management in patients with CR-GN infections are largely due to complex co-morbidities, a Non history of prior antibiotic treatment, and multiple referrals across health care facilities.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalInfectious Disease Reports
Volume12
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Antibiotic resistance
  • Carbapenem resistance
  • Clinical management
  • Gram-negative bacteria
  • Multi-drug resistance

ASJC Scopus subject areas

  • Infectious Diseases

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