Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications

Sharon Eleuteri, Alessandra Fierabracci

Research output: Contribution to journalReview article

Abstract

Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can be easily isolated and expanded in vitro. Despite being a powerful tool for clinical applications, they present limitations in terms of delivery, safety, and variability of therapeutic response. Interestingly, the MSC secretome composed by cytokines, chemokines, growth factors, proteins, and extracellular vesicles, could represent a valid alternative to their use. It is noteworthy that MSC-derived extracellular vesicles (MSC-EVs) have the same effect and could be advantageous compared to the parental cells because of their specific miRNAs load. MiRNAs could be useful both in diagnostic procedures such as "liquid biopsy" to identify early pathologies and in the therapeutic field. Not only are MSC-EVs' preservation, transfer, and production easier, but their administration is also safer, hence some clinical trials are ongoing. However, much effort is required to improve the characterization of EVs to avoid artifacts and guarantee reproducibility of the studies.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume20
Issue number18
DOIs
Publication statusPublished - Sep 17 2019

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stem cells
Stem cells
Mesenchymal Stromal Cells
Biopsy
pathology
Pathology
MicroRNAs
Chemokines
Artifacts
artifacts
safety
delivery
Intercellular Signaling Peptides and Proteins
Clinical Trials
Cytokines
proteins
Proteins
Safety
Liquids
Therapeutics

Cite this

Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications. / Eleuteri, Sharon; Fierabracci, Alessandra.

In: International Journal of Molecular Sciences, Vol. 20, No. 18, 17.09.2019.

Research output: Contribution to journalReview article

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