Insights of crosstalk between p53 protein and the MKK3/MKK6/p38 MAPK signaling pathway in cancer

Lorenzo Stramucci, Angelina Pranteda, Gianluca Bossi

Research output: Contribution to journalReview articlepeer-review

Abstract

TP53 is universally recognized as a pivotal protein in cell-cycle fate and apoptotic induction and, unsurprisingly, it is one of the most commonly hijacked control mechanisms in cancer. Recently, the kinase MKK3 emerged as a potential therapeutic target in different types of solid tumor being linked to mutant p53 gain-of-function. In this review, we summarize the delicate relationship among p53 mutational status, MKK3/MKK6 and the downstream activated master kinase p38MAPK, dissecting a finely-tuned crosstalk, in a potentially cell-context dependent scenario that urges towards a deeper characterization of the different molecular players involved in this signaling cascade and their interactions.

Original languageEnglish
Pages (from-to)131
JournalCancers
Volume10
Issue number5
DOIs
Publication statusPublished - May 1 2018

Keywords

  • MKK3/MKK6
  • Mutations
  • P38MAPK
  • P53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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