TY - JOUR
T1 - Insights of crosstalk between p53 protein and the MKK3/MKK6/p38 MAPK signaling pathway in cancer
AU - Stramucci, Lorenzo
AU - Pranteda, Angelina
AU - Bossi, Gianluca
PY - 2018/5/1
Y1 - 2018/5/1
N2 - TP53 is universally recognized as a pivotal protein in cell-cycle fate and apoptotic induction and, unsurprisingly, it is one of the most commonly hijacked control mechanisms in cancer. Recently, the kinase MKK3 emerged as a potential therapeutic target in different types of solid tumor being linked to mutant p53 gain-of-function. In this review, we summarize the delicate relationship among p53 mutational status, MKK3/MKK6 and the downstream activated master kinase p38MAPK, dissecting a finely-tuned crosstalk, in a potentially cell-context dependent scenario that urges towards a deeper characterization of the different molecular players involved in this signaling cascade and their interactions.
AB - TP53 is universally recognized as a pivotal protein in cell-cycle fate and apoptotic induction and, unsurprisingly, it is one of the most commonly hijacked control mechanisms in cancer. Recently, the kinase MKK3 emerged as a potential therapeutic target in different types of solid tumor being linked to mutant p53 gain-of-function. In this review, we summarize the delicate relationship among p53 mutational status, MKK3/MKK6 and the downstream activated master kinase p38MAPK, dissecting a finely-tuned crosstalk, in a potentially cell-context dependent scenario that urges towards a deeper characterization of the different molecular players involved in this signaling cascade and their interactions.
KW - MKK3/MKK6
KW - Mutations
KW - P38MAPK
KW - P53
UR - http://www.scopus.com/inward/record.url?scp=85047537482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047537482&partnerID=8YFLogxK
U2 - 10.3390/cancers10050131
DO - 10.3390/cancers10050131
M3 - Review article
AN - SCOPUS:85047537482
VL - 10
SP - 131
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 5
ER -