TY - JOUR
T1 - Insights on the effects of resveratrol and some of its derivatives in cancer and autoimmunity: A molecule with a dual activity
AU - Gianchecchi, E.
AU - Fierabracci, A.
N1 - Cited By :6
Export Date: 19 March 2021
Correspondence Address: Fierabracci, A.; Infectivology and Clinical Trials Research Department, Viale San Paolo 15, Italy; email: alessandra.fierabracci@opbg.net
PY - 2020
Y1 - 2020
N2 - In recent years, the interest in natural compounds exerting immunoregulatory effects has enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods and beverages, including red grapes and red wine, has been demonstrated to exert both in vitro and in vivo biological activities. More specifically, it has antiaging, cardioprotective, antioxidant, immunomodulatory, anti-inflammatory and chemopreventive activities. Due to its antiproliferative, pro-apoptotic and immunoregulatory effects, resveratrol has gained substantial attention for the treatment of cancer or autoimmunity, which represent frequently diagnosed diseases with important consequences for the health of the patients affected. The aim of the present review is to focus on the role of resveratrol in the modulation of cancer as well as of several organ-specific or systemic autoimmune diseases, including autoimmune hepatitis, type 1 diabetes mellitus, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
AB - In recent years, the interest in natural compounds exerting immunoregulatory effects has enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods and beverages, including red grapes and red wine, has been demonstrated to exert both in vitro and in vivo biological activities. More specifically, it has antiaging, cardioprotective, antioxidant, immunomodulatory, anti-inflammatory and chemopreventive activities. Due to its antiproliferative, pro-apoptotic and immunoregulatory effects, resveratrol has gained substantial attention for the treatment of cancer or autoimmunity, which represent frequently diagnosed diseases with important consequences for the health of the patients affected. The aim of the present review is to focus on the role of resveratrol in the modulation of cancer as well as of several organ-specific or systemic autoimmune diseases, including autoimmune hepatitis, type 1 diabetes mellitus, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
KW - Autoimmunity
KW - Cancer
KW - Resveratrol
U2 - 10.3390/antiox9020091
DO - 10.3390/antiox9020091
M3 - Article
VL - 9
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 2
ER -