Insights on the functional interaction between group 1 metabotropic glutamate receptors (mGluRI) and ErbB receptors

Ada Ledonne, Nicola B. Mercuri

Research output: Contribution to journalReview articlepeer-review


It is well-appreciated that phosphorylation is an essential post-translational mechanism of regulation for several proteins, including group 1 metabotropic glutamate receptors (mGluRI), mGluR1, and mGluR5 subtypes. While contributions of various serine/threonine protein kinases on mGluRI modulation have been recognized, the functional role of tyrosine kinases (TKs) is less acknowledged. Here, while describing current evidence supporting that mGluRI are targets of TKs, we mainly focus on the modulatory roles of the ErbB tyrosine kinases receptors-activated by the neurotrophic factors neuregulins (NRGs)-on mGluRI function. Available evidence suggests that mGluRI activity is tightly dependent on ErbB signaling, and that ErbB’s modulation profoundly influences mGluRI-dependent effects on neurotransmission, neuronal excitability, synaptic plasticity, and learning and memory processes.

Original languageEnglish
Article number7913
Pages (from-to)1-17
Number of pages17
JournalInternational Journal of Molecular Sciences
Issue number21
Publication statusPublished - Nov 1 2020


  • ErbB receptors
  • Glutamate
  • Group 1 metabotropic glutamate receptors (mGluRI)
  • MGluR1
  • MGluR5
  • Neuregulins
  • Tyrosine kinases

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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