Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism

Alessandro Serretti, Cristina Cusin, Francesco Benedetti, Laura Mandelli, Adele Pirovano, Raffaella Zanardi, Cristina Colombo, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


Sleep disturbances are commonly observed in mood disorders, and sleep manipulations can influence the clinical status. In the present study, we investigated the possible effect of the 3111 T/C circadian locomotor output cycles kaput (CLOCK) gene polymorphism on insomnia symptomatology during antidepressant treatment. One hundred seventy-eight inpatients were treated with fluvoxamine 300 mg/day (n = 147) or paroxetine 20-40 mg/day (n = 31), and either placebo or pindolol in a double blind design for 6 weeks. The severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression (HAM-D). We observed a significantly higher presence of insomnia throughout the trial in homozygotes for the C variant (P = 0.026). Other demographic and clinical features were found not to be related with CLOCK polymorphisms. Overall, our findings may suggest that CLOCK genotype influences the time course of insomnia during antidepressant treatment. This, together with previous findings on this polymorphism could lead to a further dissection of the complexity of mood disorders.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume137 B
Issue number1
Publication statusPublished - Aug 5 2005


  • Bipolar disorder
  • Circadian rhythm
  • CLOCK gene
  • Insomnia
  • Major depressive disorder
  • Pharmacogenetics

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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