Instability and impending instability in patients with vertebral metastatic disease

Antonio Leone, Alessandro Cianfoni, Viola Zecchi, Maria Cristina Cortese, Nicolò Rumi, Cesare Colosimo

Research output: Contribution to journalReview article

Abstract

Metastatic disease commonly involves the spine with an increasing incidence due to a worldwide rise of cancer incidence and a longer survival of patients with osseous metastases. Metastases compromise the mechanical integrity of the vertebra and make it susceptible to fracture. Patients with pathological vertebral fracture often become symptomatic, with mechanical pain generally due to intervertebral instability, and may develop spinal cord compression and neurological deficits. Advances in imaging, radiotherapy, as well as in spinal surgery techniques, have allowed the evolution from conventional palliative external beam radiotherapy to modern stereotactic radiosurgery and from traditional open surgery to less-invasive, and sometimes prophylactic stabilization surgical treatments. It is therefore clear that fracture risk prediction, and maintenance or restoration of intervertebral stability, are important objectives in the management of these patients. Correlation between imaging findings and clinical manifestations is crucial, and a common knowledge base for treatment team members rather than a compartmentalized view is very important. This article reviews the literature on the imaging and clinical diagnosis of intervertebral instability and impending instability in the setting of spine metastatic disease, including the spinal instability neoplastic score, which is a reliable tool for diagnosing unstable or potentially unstable metastatic spinal lesions, and on the different elements considered for treatment.

Original languageEnglish
Pages (from-to)195-207
Number of pages13
JournalSkeletal Radiology
Volume48
Issue number2
DOIs
Publication statusE-pub ahead of print - Aug 1 2018

Fingerprint

Spine
Radiotherapy
Spinal Diseases
Neoplasm Metastasis
Spontaneous Fractures
Spinal Cord Compression
Knowledge Bases
Radiosurgery
Incidence
Therapeutics
Maintenance
Pain
Survival
Neoplasms

Keywords

  • Humans
  • Joint Instability/diagnostic imaging
  • Spinal Fractures/diagnostic imaging
  • Spinal Neoplasms/diagnostic imaging

Cite this

Instability and impending instability in patients with vertebral metastatic disease. / Leone, Antonio; Cianfoni, Alessandro; Zecchi, Viola; Cortese, Maria Cristina; Rumi, Nicolò; Colosimo, Cesare.

In: Skeletal Radiology, Vol. 48, No. 2, 01.08.2018, p. 195-207.

Research output: Contribution to journalReview article

Leone, Antonio ; Cianfoni, Alessandro ; Zecchi, Viola ; Cortese, Maria Cristina ; Rumi, Nicolò ; Colosimo, Cesare. / Instability and impending instability in patients with vertebral metastatic disease. In: Skeletal Radiology. 2018 ; Vol. 48, No. 2. pp. 195-207.
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