Gait and balance deficits are major impairments for Charcot-Marie-Tooth 1A (CMT1A) patients. However, motor rehabilitation is a challenge in CMT1A patients. There are poor evidences of clinical efficacy and low responsive outcome measures. Instrumented assessment (like inertial sensors) might be new tools to detect patient’s changes. A small sample of CMT1A was assessed before and after the rehabilitation period. Traditional and instrumented assessment measures of gait and balance were used. Results shown that only six-minute walking test showed an improvement after rehabilitation, in all patients. The Instrumented Timed Up and Go subtasks duration did not show responsiveness in CMT1A patients.