Insufficiency Fractures After Radiation Therapy: An Update

Vincenzo Fusco, Rocchina Caivano, Salvatore Parisi, Michele Troiano, Pietro Corsa, Arcangela Raguso, Tindara Munafò, Maria Antonietta Clemente, Giuseppe Guglielmi

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: Radio therapy, alone or in combination with surgery and/or chemotherapy, is commonly used to treat a variety of neoplasms, resulting in effective local tumor control. Unfortunately radiation therapy can also change the structure of the skeletal system, leading to edema, vascular congestion, areas of hemorrhage, loss of cellularity, focal bone marrow changes, fatty transformation, osteitis, hematopoietic marrow regeneration, osteolysis of symphysis pubis or sacroiliac joints, avascular necrosis, insufficiency fractures, osteoradionecrosis, and radiation-induced neoplasms. Recent Findings: The various radiotherapy effects can be studied and diagnosed by analyzing MR signal intensity, CT attenuation, and FDG-PET activity. Summary: In this review, we report a complete analysis of side effects of radiotherapy on bones, focusing on the spine, chest wall, and pelvis.

Original languageEnglish
Article number21
JournalCurrent Radiology Reports
Issue number7
Publication statusPublished - Jul 1 2018


  • Bones
  • Imaging
  • Insufficiency fractures
  • Radiotherapy (RT)
  • Side effects

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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