Insufficiency Fractures After Radiation Therapy

An Update

Vincenzo Fusco, Rocchina Caivano, Salvatore Parisi, Michele Troiano, Pietro Corsa, Arcangela Raguso, Tindara Munafò, Maria Antonietta Clemente, Giuseppe Guglielmi

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Radio therapy, alone or in combination with surgery and/or chemotherapy, is commonly used to treat a variety of neoplasms, resulting in effective local tumor control. Unfortunately radiation therapy can also change the structure of the skeletal system, leading to edema, vascular congestion, areas of hemorrhage, loss of cellularity, focal bone marrow changes, fatty transformation, osteitis, hematopoietic marrow regeneration, osteolysis of symphysis pubis or sacroiliac joints, avascular necrosis, insufficiency fractures, osteoradionecrosis, and radiation-induced neoplasms. Recent Findings: The various radiotherapy effects can be studied and diagnosed by analyzing MR signal intensity, CT attenuation, and FDG-PET activity. Summary: In this review, we report a complete analysis of side effects of radiotherapy on bones, focusing on the spine, chest wall, and pelvis.

Original languageEnglish
Article number21
JournalCurrent Radiology Reports
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Stress Fractures
Radiotherapy
Pubic Bone
Bone Marrow
Radiation-Induced Neoplasms
Osteoradionecrosis
Sacroiliac Joint
Osteitis
Osteolysis
Thoracic Wall
Pelvis
Radio
Blood Vessels
Regeneration
Edema
Neoplasms
Spine
Necrosis
Hemorrhage
Bone and Bones

Keywords

  • Bones
  • Imaging
  • Insufficiency fractures
  • Radiotherapy (RT)
  • Side effects

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Insufficiency Fractures After Radiation Therapy : An Update. / Fusco, Vincenzo; Caivano, Rocchina; Parisi, Salvatore; Troiano, Michele; Corsa, Pietro; Raguso, Arcangela; Munafò, Tindara; Clemente, Maria Antonietta; Guglielmi, Giuseppe.

In: Current Radiology Reports, Vol. 6, No. 7, 21, 01.07.2018.

Research output: Contribution to journalReview article

Fusco, Vincenzo ; Caivano, Rocchina ; Parisi, Salvatore ; Troiano, Michele ; Corsa, Pietro ; Raguso, Arcangela ; Munafò, Tindara ; Clemente, Maria Antonietta ; Guglielmi, Giuseppe. / Insufficiency Fractures After Radiation Therapy : An Update. In: Current Radiology Reports. 2018 ; Vol. 6, No. 7.
@article{d0ca6f6eb6784f2a9a303e90c85489f4,
title = "Insufficiency Fractures After Radiation Therapy: An Update",
abstract = "Purpose of Review: Radio therapy, alone or in combination with surgery and/or chemotherapy, is commonly used to treat a variety of neoplasms, resulting in effective local tumor control. Unfortunately radiation therapy can also change the structure of the skeletal system, leading to edema, vascular congestion, areas of hemorrhage, loss of cellularity, focal bone marrow changes, fatty transformation, osteitis, hematopoietic marrow regeneration, osteolysis of symphysis pubis or sacroiliac joints, avascular necrosis, insufficiency fractures, osteoradionecrosis, and radiation-induced neoplasms. Recent Findings: The various radiotherapy effects can be studied and diagnosed by analyzing MR signal intensity, CT attenuation, and FDG-PET activity. Summary: In this review, we report a complete analysis of side effects of radiotherapy on bones, focusing on the spine, chest wall, and pelvis.",
keywords = "Bones, Imaging, Insufficiency fractures, Radiotherapy (RT), Side effects",
author = "Vincenzo Fusco and Rocchina Caivano and Salvatore Parisi and Michele Troiano and Pietro Corsa and Arcangela Raguso and Tindara Munaf{\`o} and Clemente, {Maria Antonietta} and Giuseppe Guglielmi",
year = "2018",
month = "7",
day = "1",
doi = "10.1007/s40134-018-0280-x",
language = "English",
volume = "6",
journal = "Current Radiology Reports",
issn = "2167-4825",
publisher = "Springer New York",
number = "7",

}

TY - JOUR

T1 - Insufficiency Fractures After Radiation Therapy

T2 - An Update

AU - Fusco, Vincenzo

AU - Caivano, Rocchina

AU - Parisi, Salvatore

AU - Troiano, Michele

AU - Corsa, Pietro

AU - Raguso, Arcangela

AU - Munafò, Tindara

AU - Clemente, Maria Antonietta

AU - Guglielmi, Giuseppe

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Purpose of Review: Radio therapy, alone or in combination with surgery and/or chemotherapy, is commonly used to treat a variety of neoplasms, resulting in effective local tumor control. Unfortunately radiation therapy can also change the structure of the skeletal system, leading to edema, vascular congestion, areas of hemorrhage, loss of cellularity, focal bone marrow changes, fatty transformation, osteitis, hematopoietic marrow regeneration, osteolysis of symphysis pubis or sacroiliac joints, avascular necrosis, insufficiency fractures, osteoradionecrosis, and radiation-induced neoplasms. Recent Findings: The various radiotherapy effects can be studied and diagnosed by analyzing MR signal intensity, CT attenuation, and FDG-PET activity. Summary: In this review, we report a complete analysis of side effects of radiotherapy on bones, focusing on the spine, chest wall, and pelvis.

AB - Purpose of Review: Radio therapy, alone or in combination with surgery and/or chemotherapy, is commonly used to treat a variety of neoplasms, resulting in effective local tumor control. Unfortunately radiation therapy can also change the structure of the skeletal system, leading to edema, vascular congestion, areas of hemorrhage, loss of cellularity, focal bone marrow changes, fatty transformation, osteitis, hematopoietic marrow regeneration, osteolysis of symphysis pubis or sacroiliac joints, avascular necrosis, insufficiency fractures, osteoradionecrosis, and radiation-induced neoplasms. Recent Findings: The various radiotherapy effects can be studied and diagnosed by analyzing MR signal intensity, CT attenuation, and FDG-PET activity. Summary: In this review, we report a complete analysis of side effects of radiotherapy on bones, focusing on the spine, chest wall, and pelvis.

KW - Bones

KW - Imaging

KW - Insufficiency fractures

KW - Radiotherapy (RT)

KW - Side effects

UR - http://www.scopus.com/inward/record.url?scp=85061691068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061691068&partnerID=8YFLogxK

U2 - 10.1007/s40134-018-0280-x

DO - 10.1007/s40134-018-0280-x

M3 - Review article

VL - 6

JO - Current Radiology Reports

JF - Current Radiology Reports

SN - 2167-4825

IS - 7

M1 - 21

ER -