Insulin action on glucose kinetics: New developments from a two-compartment tracer minimal model

Andrea Caumo, Claudio Cobelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A two-compartment minimal model of tracer kinetics during a labeled IVGTT (intravenous glucose tolerance test) was proposed recently. The model predicts a plausible time course of hepatic glucose production during the test, thus overcoming the inadequacy of the classical single-compartment tracer minimal model. In the present work, the authors discuss the ability of the model to yield a description of glucose kinetics and the effect of insulin upon it. In particular, it is shown that the model provides metabolic indices measuring plasma clearance rate and insulin sensitivity. Finally, the time course of insulin action and the metabolic indices of the model are compared with those provided by the classical tracer minimal model. The insulin sensitivity indices provided by the two models, when expressed in the same units, are not different and well correlated.

Original languageEnglish
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
PublisherPubl by IEEE
Pages1002-1003
Number of pages2
Editionpt 3
ISBN (Print)0879425598
Publication statusPublished - 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

ASJC Scopus subject areas

  • Bioengineering

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