Insulin and gall stones

A population case control study in southern Italy

G. Misciagna, V. Guerra, A. Di Leo, M. Correale, M. Trevisan

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background - Hyperinsulinaemia has been associated with many common diseases in developed countries, such as ischaemic heart disease and colon cancer. Gall stones are also very prevalent in these countries but little is known about the association between insulin and gall stones. Aims - To study the relationships between insulin and the incidence of gall stones in a sample of the general population. Subjects and methods - Between May 1985 and June 1986, systematic sampling from the electoral register of Castellana, a small town in southern Italy, yielded 2472 subjects who had their gall bladder checked for gall stones by ultrasonography. Between May 1992 and June 1993, 1962 of the 2235 subjects without gall stones at the first examination agreed to a further ultrasound examination. A total of 101 subjects with newly diagnosed gall stones and 303 randomly chosen controls entered the study. Serum insulin was determined by radioimmunoassay, and concentrations of cholesterol, cholesterol high density lipoprotein (HDL), glucose, and triglycerides by standard enzymatic colorimetric methods. Unconditional multiple logistic regression was used to study the association between insulin and gall stones, controlling for the most common confounding factors. Results - In individuals with no clinical diagnosis of diabetes and serum glucose 2 test for trend, p=0.03). The association of insulin with gall stones persisted when total and HDL cholesterol were entered in the logistic regression models, and only slightly decreased when serum triglycerides were included in the model. Conclusions - The results of the study indicate that hyperinsulinaemia may play an important role in the aetiology of gall stones even in individuals without diabetes and with normal serum glucose levels.

Original languageEnglish
Pages (from-to)144-147
Number of pages4
JournalGut
Volume47
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Population Control
Gallstones
Italy
Case-Control Studies
Insulin
Logistic Models
Hyperinsulinism
Serum
Glucose
HDL Cholesterol
Triglycerides
Heart Neoplasms
Developed Countries
Colonic Neoplasms
Radioimmunoassay
Myocardial Ischemia
Ultrasonography
Urinary Bladder
Cholesterol
Incidence

Keywords

  • Case control study
  • Epidemiology
  • Gallstones
  • Insulin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Misciagna, G., Guerra, V., Di Leo, A., Correale, M., & Trevisan, M. (2000). Insulin and gall stones: A population case control study in southern Italy. Gut, 47(1), 144-147. https://doi.org/10.1136/gut.47.1.144

Insulin and gall stones : A population case control study in southern Italy. / Misciagna, G.; Guerra, V.; Di Leo, A.; Correale, M.; Trevisan, M.

In: Gut, Vol. 47, No. 1, 2000, p. 144-147.

Research output: Contribution to journalArticle

Misciagna, G, Guerra, V, Di Leo, A, Correale, M & Trevisan, M 2000, 'Insulin and gall stones: A population case control study in southern Italy', Gut, vol. 47, no. 1, pp. 144-147. https://doi.org/10.1136/gut.47.1.144
Misciagna, G. ; Guerra, V. ; Di Leo, A. ; Correale, M. ; Trevisan, M. / Insulin and gall stones : A population case control study in southern Italy. In: Gut. 2000 ; Vol. 47, No. 1. pp. 144-147.
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